HYDROGEN PEROXIDE-INDUCED OXIDATIVE DAMAGE AND APOPTOSIS IN CEREBELLAR GRANULE CELLS: PROTECTION BY GINKGO BILOBA EXTRACT

The ability of oxidative stress to induce apoptosis and the protective effects of Ginkgo biloba extract (EGb761) against this induction were studied in cultures of rat cerebellar granule cells. Cells were exposed to oxidative stress by treatment with 50 μm hydrogen peroxide+100 μm ferrous sulphate w...

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Veröffentlicht in:	Pharmacological research 2000-04, Vol.41 (4), p.427-433
Hauptverfasser:	WEI, TAOTAO, NI, YUCHENG, HOU, JINGWU, CHEN, CHANG, ZHAO, BAOLU, XIN, WENJUAN
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidants - pharmacology Apoptosis - drug effects apoptosis, cerebellar granule cells, EGb761, lipid peroxidation, ESR spin labelling Cell Membrane - drug effects Cell Survival - drug effects Cells, Cultured Cerebellum - cytology Cerebellum - drug effects Cytoplasmic Granules - drug effects Cytoplasmic Granules - ultrastructure DNA Fragmentation - drug effects Electron Spin Resonance Spectroscopy Ferric Compounds - pharmacology Flavonoids - pharmacology Ginkgo biloba Hydrogen Peroxide - toxicity Lipid Peroxidation - drug effects Neurons - drug effects Neurons - ultrastructure Oxidants - toxicity Oxidative Stress - drug effects Plant Extracts Rats Rats, Wistar Spin Labels
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