ELTANOLONE (5-β-PREGNANOLONE) DOES NOT TRIGGER, AND ATTENUATES HALOTHANE TRIGGERING OF, MALIGNANT HYPERTHERMIA IN MALIGNANT HYPERTHERMIA SUSCEPTIBLE SWINE

Eltanolone is the lipid emulsion formulation, for intravenous use, of the steroid anaesthetic 5-β-pregnanolone. We have screened this agent in malignant hyperthermia susceptible (MHS) Landrace swine to assess its potential to trigger the Malignant Hyperthermia (MH) syndrome in MHS subjects or to inf...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Pharmacological research 1999-02, Vol.39 (2), p.103-106
Hauptverfasser:	HARRISON, G.G., DYER, R.A., LLEWELLYN, R.L., JAMES, M.F.M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthetics, Inhalation - toxicity Animals Body Temperature - drug effects Capnography Drug Antagonism Electrocardiography eltanolone Halothane - toxicity Malignant Hyperthermia - genetics Malignant Hyperthermia - prevention & control malignant hyperthermia — blocking/attenuation malignant hyperthermia — safe drugs Pregnanolone - pharmacology steroid anaesthesia Swine
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!