Antagonism of Medetomidine-Induced Ataxia in Rats by Yohimbine, Aminophylline and Caffeine

The actions of the α 2-antagonist yohimbine and methylxanthines aminophylline and caffeine were evaluated in reversing ataxia, increase in landing foot splay (LFS), produced by the α 2-agonist medetomidine in male rats. Medetomidine at 0.1 and 0.15 mg/kg, i.p. increased LFS by 42.9 and 69.6%, respec...

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Veröffentlicht in:	Pharmacological research 1993, Vol.27 (1), p.81-88
Hauptverfasser:	Mohammad, F.K., Dawood, K.A., Al-Dabbagh, S.G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic alpha-Agonists - antagonists & inhibitors Aminophylline - pharmacology Animals Ataxia - chemically induced Ataxia - drug therapy Biological and medical sciences Caffeine - pharmacology Clonidine - analogs & derivatives Clonidine - antagonists & inhibitors Drug toxicity and drugs side effects treatment Hypnotics and Sedatives - antagonists & inhibitors Imidazoles - antagonists & inhibitors Male Medetomidine medetomidine, yohimbine, aminophylline, caffeine, α 2-agonist-antagonist, ataxia Medical sciences Pharmacology. Drug treatments Rats Toxicity: nervous system and muscle Yohimbine - pharmacology
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