Antibody to Day-Old Chick Brain Glycoprotein Produces Amnesia in Adult Rats
Polyclonal antibody R-1, raised against a chick synaptic membrane glycoprotein fraction whose synthesis is enhanced following training on a passive avoidance task, produces amnesia when injected into chick forebrain 5.5 h posttraining. The amnestic IgG fraction specifically recognizes a low sialylat...
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| Veröffentlicht in: | Neurobiology of learning and memory 1997-01, Vol.67 (1), p.14-20 |
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| container_title | Neurobiology of learning and memory |
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| creator | Alexinsky, T. Przybyslawski, J. Mileusnic, R. Rose, S.P.R. Sara, S.J. |
| description | Polyclonal antibody R-1, raised against a chick synaptic membrane glycoprotein fraction whose synthesis is enhanced following training on a passive avoidance task, produces amnesia when injected into chick forebrain 5.5 h posttraining. The amnestic IgG fraction specifically recognizes a low sialylated isoform of NCAM (Mileusnic, Rose, Lancashire, & Bullock, 1995). We have now investigated the effects of this antibody on memory formation in adult rats. R-1, preimmune serum, or saline was injected intracerebroventricularly 5.5 h posttraining through bilaterally implanted cannulae. Rats injected with R-1 and tested 48 h later showed a significant amnesia for avoidance compared with the controls. Amnesia was not apparent at 24 h posttraining. R-1 injections were without effect on spontaneous locomotor or exploratory activity in a hole-board test. The results contribute to the argument that the role of cell adhesion molecules in neuronal plasticity is not limited to the developing nervous system, but they play a more general role in the experience-dependent synaptic remodeling underlying long-term memory. |
| doi_str_mv | 10.1006/nlme.1996.3734 |
| format | Article |
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The amnestic IgG fraction specifically recognizes a low sialylated isoform of NCAM (Mileusnic, Rose, Lancashire, & Bullock, 1995). We have now investigated the effects of this antibody on memory formation in adult rats. R-1, preimmune serum, or saline was injected intracerebroventricularly 5.5 h posttraining through bilaterally implanted cannulae. Rats injected with R-1 and tested 48 h later showed a significant amnesia for avoidance compared with the controls. Amnesia was not apparent at 24 h posttraining. R-1 injections were without effect on spontaneous locomotor or exploratory activity in a hole-board test. The results contribute to the argument that the role of cell adhesion molecules in neuronal plasticity is not limited to the developing nervous system, but they play a more general role in the experience-dependent synaptic remodeling underlying long-term memory.</description><identifier>ISSN: 1074-7427</identifier><identifier>EISSN: 1095-9564</identifier><identifier>DOI: 10.1006/nlme.1996.3734</identifier><identifier>PMID: 9013496</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>Amnesia - chemically induced ; Animals ; Antibodies - adverse effects ; Antibodies - pharmacology ; Behavior, Animal - drug effects ; Behavioral psychophysiology ; Biological and medical sciences ; Cell Adhesion Molecules - physiology ; Cross Reactions ; Exploratory Behavior - drug effects ; Fundamental and applied biological sciences. Psychology ; Glycoproteins - biosynthesis ; Male ; Memory - drug effects ; Miscellaneous ; Neuronal Plasticity ; Prosencephalon - drug effects ; Psychology. Psychoanalysis. Psychiatry ; Psychology. Psychophysiology ; Rats ; Rats, Sprague-Dawley ; Retention (Psychology) - drug effects ; Synaptic Membranes - drug effects</subject><ispartof>Neurobiology of learning and memory, 1997-01, Vol.67 (1), p.14-20</ispartof><rights>1997 Academic Press</rights><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c368t-e6da36c39673bf123d07a4b1d598107fabd58011527bf9b515c98eebb958ea723</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1006/nlme.1996.3734$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,4024,27923,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2544168$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9013496$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Alexinsky, T.</creatorcontrib><creatorcontrib>Przybyslawski, J.</creatorcontrib><creatorcontrib>Mileusnic, R.</creatorcontrib><creatorcontrib>Rose, S.P.R.</creatorcontrib><creatorcontrib>Sara, S.J.</creatorcontrib><title>Antibody to Day-Old Chick Brain Glycoprotein Produces Amnesia in Adult Rats</title><title>Neurobiology of learning and memory</title><addtitle>Neurobiol Learn Mem</addtitle><description>Polyclonal antibody R-1, raised against a chick synaptic membrane glycoprotein fraction whose synthesis is enhanced following training on a passive avoidance task, produces amnesia when injected into chick forebrain 5.5 h posttraining. The amnestic IgG fraction specifically recognizes a low sialylated isoform of NCAM (Mileusnic, Rose, Lancashire, & Bullock, 1995). We have now investigated the effects of this antibody on memory formation in adult rats. R-1, preimmune serum, or saline was injected intracerebroventricularly 5.5 h posttraining through bilaterally implanted cannulae. Rats injected with R-1 and tested 48 h later showed a significant amnesia for avoidance compared with the controls. Amnesia was not apparent at 24 h posttraining. R-1 injections were without effect on spontaneous locomotor or exploratory activity in a hole-board test. The results contribute to the argument that the role of cell adhesion molecules in neuronal plasticity is not limited to the developing nervous system, but they play a more general role in the experience-dependent synaptic remodeling underlying long-term memory.</description><subject>Amnesia - chemically induced</subject><subject>Animals</subject><subject>Antibodies - adverse effects</subject><subject>Antibodies - pharmacology</subject><subject>Behavior, Animal - drug effects</subject><subject>Behavioral psychophysiology</subject><subject>Biological and medical sciences</subject><subject>Cell Adhesion Molecules - physiology</subject><subject>Cross Reactions</subject><subject>Exploratory Behavior - drug effects</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Glycoproteins - biosynthesis</subject><subject>Male</subject><subject>Memory - drug effects</subject><subject>Miscellaneous</subject><subject>Neuronal Plasticity</subject><subject>Prosencephalon - drug effects</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Retention (Psychology) - drug effects</subject><subject>Synaptic Membranes - drug effects</subject><issn>1074-7427</issn><issn>1095-9564</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kMtLw0AQxhdRaq1evQk5eE3czT6SPcaqVSxURM9hHxNczaPspkL-exNaevM0r2-Gb34IXROcEIzFXVs3kBApRUIzyk7QnGDJY8kFO53yjMUZS7NzdBHCN8aEcJnP0ExiQpkUc_RatL3TnR2ivose1BBvahstv5z5ie69cm20qgfTbX3Xw1i8-c7uDISoaFoITkVjr7C7uo_eVR8u0Vml6gBXh7hAn0-PH8vneL1ZvSyLdWyoyPsYhFVUGCpFRnVFUmpxppgmdrQ2Gq6UtjyfnKaZrqTmhBuZA2gteQ4qS-kCJfu7xncheKjKrXeN8kNJcDlBKSco5QSlnKCMCzf7he1ON2CP8gOFcX57mKtgVF151RoXjrKUM0ZEPsryvQzG534d-DIYB60B6zyYvrSd-8_BH5NcfL0</recordid><startdate>199701</startdate><enddate>199701</enddate><creator>Alexinsky, T.</creator><creator>Przybyslawski, J.</creator><creator>Mileusnic, R.</creator><creator>Rose, S.P.R.</creator><creator>Sara, S.J.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>199701</creationdate><title>Antibody to Day-Old Chick Brain Glycoprotein Produces Amnesia in Adult Rats</title><author>Alexinsky, T. ; Przybyslawski, J. ; Mileusnic, R. ; Rose, S.P.R. ; Sara, S.J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c368t-e6da36c39673bf123d07a4b1d598107fabd58011527bf9b515c98eebb958ea723</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Amnesia - chemically induced</topic><topic>Animals</topic><topic>Antibodies - adverse effects</topic><topic>Antibodies - pharmacology</topic><topic>Behavior, Animal - drug effects</topic><topic>Behavioral psychophysiology</topic><topic>Biological and medical sciences</topic><topic>Cell Adhesion Molecules - physiology</topic><topic>Cross Reactions</topic><topic>Exploratory Behavior - drug effects</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Glycoproteins - biosynthesis</topic><topic>Male</topic><topic>Memory - drug effects</topic><topic>Miscellaneous</topic><topic>Neuronal Plasticity</topic><topic>Prosencephalon - drug effects</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychology. Psychophysiology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Retention (Psychology) - drug effects</topic><topic>Synaptic Membranes - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Alexinsky, T.</creatorcontrib><creatorcontrib>Przybyslawski, J.</creatorcontrib><creatorcontrib>Mileusnic, R.</creatorcontrib><creatorcontrib>Rose, S.P.R.</creatorcontrib><creatorcontrib>Sara, S.J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Neurobiology of learning and memory</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Alexinsky, T.</au><au>Przybyslawski, J.</au><au>Mileusnic, R.</au><au>Rose, S.P.R.</au><au>Sara, S.J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antibody to Day-Old Chick Brain Glycoprotein Produces Amnesia in Adult Rats</atitle><jtitle>Neurobiology of learning and memory</jtitle><addtitle>Neurobiol Learn Mem</addtitle><date>1997-01</date><risdate>1997</risdate><volume>67</volume><issue>1</issue><spage>14</spage><epage>20</epage><pages>14-20</pages><issn>1074-7427</issn><eissn>1095-9564</eissn><abstract>Polyclonal antibody R-1, raised against a chick synaptic membrane glycoprotein fraction whose synthesis is enhanced following training on a passive avoidance task, produces amnesia when injected into chick forebrain 5.5 h posttraining. The amnestic IgG fraction specifically recognizes a low sialylated isoform of NCAM (Mileusnic, Rose, Lancashire, & Bullock, 1995). We have now investigated the effects of this antibody on memory formation in adult rats. R-1, preimmune serum, or saline was injected intracerebroventricularly 5.5 h posttraining through bilaterally implanted cannulae. Rats injected with R-1 and tested 48 h later showed a significant amnesia for avoidance compared with the controls. Amnesia was not apparent at 24 h posttraining. R-1 injections were without effect on spontaneous locomotor or exploratory activity in a hole-board test. The results contribute to the argument that the role of cell adhesion molecules in neuronal plasticity is not limited to the developing nervous system, but they play a more general role in the experience-dependent synaptic remodeling underlying long-term memory.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>9013496</pmid><doi>10.1006/nlme.1996.3734</doi><tpages>7</tpages></addata></record> |
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| ispartof | Neurobiology of learning and memory, 1997-01, Vol.67 (1), p.14-20 |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Amnesia - chemically induced Animals Antibodies - adverse effects Antibodies - pharmacology Behavior, Animal - drug effects Behavioral psychophysiology Biological and medical sciences Cell Adhesion Molecules - physiology Cross Reactions Exploratory Behavior - drug effects Fundamental and applied biological sciences. Psychology Glycoproteins - biosynthesis Male Memory - drug effects Miscellaneous Neuronal Plasticity Prosencephalon - drug effects Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Rats Rats, Sprague-Dawley Retention (Psychology) - drug effects Synaptic Membranes - drug effects |
| title | Antibody to Day-Old Chick Brain Glycoprotein Produces Amnesia in Adult Rats |
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