Indomethacin-Induced Disturbances in Villous Microcirculation in the Rat Ileum
Indomethacin is a widely used nonsteroidal antiphlogistic compound used—among others—for the treatment of rheumatoid arthritis in humans. Common side effects of indomethacin in the gastrointestinal tract include ulcerative lesions and petechial bleeding in the mucosa. In the rat, oral intake of indo...
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| Veröffentlicht in: | Microvascular research 1999-09, Vol.58 (2), p.137-143 |
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| creator | Ruh, Joachim Schmidt, Eduard Vogel, Frank Klar, Ernst |
| description | Indomethacin is a widely used nonsteroidal antiphlogistic compound used—among others—for the treatment of rheumatoid arthritis in humans. Common side effects of indomethacin in the gastrointestinal tract include ulcerative lesions and petechial bleeding in the mucosa. In the rat, oral intake of indomethacin induces ulcerations in the mucosa of the stomach and, if administered systemically, edema, petechial bleeding, and ulcerations in the small intestine. In order to determine if systemic administration of indomethacin may induce changes in villous perfusion, we assessed the effect of indomethacin on erythrocyte velocity and the diameter of the main arteriole in the villi of the rat ileum. We found that indomethacin led to a significant decrease in mean arteriolar blood flow (6.3 ± 0.8 vs 5.0 ± 1.2 nl/min, means ± SD) 7 days after administration. Mean diameter of the main arteriole remained unchanged (control, 7.8 ± 0.8 vs indomethacin, 7.0 ± 0.9 μm). In conclusion, systemic application of indomethacin leads to a decrease in blood supply to the mucosa. We previously found an increase in villous perfusion when assessed 24 h after administration of indomethacin, accompanied by an increase in arteriolar diameter of the main arteriole. In summary, different regimens of application of indomethacin lead to varying observations in microcirculatory parameters in single villi. Further studies are required to identify the underlying mechanisms. |
| doi_str_mv | 10.1006/mvre.1999.2162 |
| format | Article |
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Common side effects of indomethacin in the gastrointestinal tract include ulcerative lesions and petechial bleeding in the mucosa. In the rat, oral intake of indomethacin induces ulcerations in the mucosa of the stomach and, if administered systemically, edema, petechial bleeding, and ulcerations in the small intestine. In order to determine if systemic administration of indomethacin may induce changes in villous perfusion, we assessed the effect of indomethacin on erythrocyte velocity and the diameter of the main arteriole in the villi of the rat ileum. We found that indomethacin led to a significant decrease in mean arteriolar blood flow (6.3 ± 0.8 vs 5.0 ± 1.2 nl/min, means ± SD) 7 days after administration. Mean diameter of the main arteriole remained unchanged (control, 7.8 ± 0.8 vs indomethacin, 7.0 ± 0.9 μm). In conclusion, systemic application of indomethacin leads to a decrease in blood supply to the mucosa. We previously found an increase in villous perfusion when assessed 24 h after administration of indomethacin, accompanied by an increase in arteriolar diameter of the main arteriole. In summary, different regimens of application of indomethacin lead to varying observations in microcirculatory parameters in single villi. Further studies are required to identify the underlying mechanisms.</description><identifier>ISSN: 0026-2862</identifier><identifier>EISSN: 1095-9319</identifier><identifier>DOI: 10.1006/mvre.1999.2162</identifier><identifier>PMID: 10458929</identifier><identifier>CODEN: MIVRA6</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>Animals ; Anti-Inflammatory Agents, Non-Steroidal - toxicity ; Arterioles - drug effects ; Arterioles - pathology ; Arterioles - physiopathology ; Biological and medical sciences ; Blood Flow Velocity - drug effects ; Drug toxicity and drugs side effects treatment ; Humans ; Ileum - blood supply ; Ileum - drug effects ; indomethacin ; Indomethacin - toxicity ; Inflammation - chemically induced ; Inflammation - pathology ; Intestinal Mucosa - blood supply ; Intestinal Mucosa - drug effects ; Male ; Medical sciences ; Microcirculation - drug effects ; Pharmacology. Drug treatments ; rat small intestine ; Rats ; Rats, Sprague-Dawley ; Toxicity: digestive system ; villous microcirculation</subject><ispartof>Microvascular research, 1999-09, Vol.58 (2), p.137-143</ispartof><rights>1999 Academic Press</rights><rights>1999 INIST-CNRS</rights><rights>Copyright 1999 Academic Press.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c369t-ea40a66c390e3613efa335d2a069411f04b88ad2e8c2aafe6059960a339c76d03</citedby><cites>FETCH-LOGICAL-c369t-ea40a66c390e3613efa335d2a069411f04b88ad2e8c2aafe6059960a339c76d03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1006/mvre.1999.2162$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3549,27923,27924,45994</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1963845$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10458929$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ruh, Joachim</creatorcontrib><creatorcontrib>Schmidt, Eduard</creatorcontrib><creatorcontrib>Vogel, Frank</creatorcontrib><creatorcontrib>Klar, Ernst</creatorcontrib><title>Indomethacin-Induced Disturbances in Villous Microcirculation in the Rat Ileum</title><title>Microvascular research</title><addtitle>Microvasc Res</addtitle><description>Indomethacin is a widely used nonsteroidal antiphlogistic compound used—among others—for the treatment of rheumatoid arthritis in humans. Common side effects of indomethacin in the gastrointestinal tract include ulcerative lesions and petechial bleeding in the mucosa. In the rat, oral intake of indomethacin induces ulcerations in the mucosa of the stomach and, if administered systemically, edema, petechial bleeding, and ulcerations in the small intestine. In order to determine if systemic administration of indomethacin may induce changes in villous perfusion, we assessed the effect of indomethacin on erythrocyte velocity and the diameter of the main arteriole in the villi of the rat ileum. We found that indomethacin led to a significant decrease in mean arteriolar blood flow (6.3 ± 0.8 vs 5.0 ± 1.2 nl/min, means ± SD) 7 days after administration. Mean diameter of the main arteriole remained unchanged (control, 7.8 ± 0.8 vs indomethacin, 7.0 ± 0.9 μm). In conclusion, systemic application of indomethacin leads to a decrease in blood supply to the mucosa. We previously found an increase in villous perfusion when assessed 24 h after administration of indomethacin, accompanied by an increase in arteriolar diameter of the main arteriole. In summary, different regimens of application of indomethacin lead to varying observations in microcirculatory parameters in single villi. Further studies are required to identify the underlying mechanisms.</description><subject>Animals</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - toxicity</subject><subject>Arterioles - drug effects</subject><subject>Arterioles - pathology</subject><subject>Arterioles - physiopathology</subject><subject>Biological and medical sciences</subject><subject>Blood Flow Velocity - drug effects</subject><subject>Drug toxicity and drugs side effects treatment</subject><subject>Humans</subject><subject>Ileum - blood supply</subject><subject>Ileum - drug effects</subject><subject>indomethacin</subject><subject>Indomethacin - toxicity</subject><subject>Inflammation - chemically induced</subject><subject>Inflammation - pathology</subject><subject>Intestinal Mucosa - blood supply</subject><subject>Intestinal Mucosa - drug effects</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microcirculation - drug effects</subject><subject>Pharmacology. Drug treatments</subject><subject>rat small intestine</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Toxicity: digestive system</subject><subject>villous microcirculation</subject><issn>0026-2862</issn><issn>1095-9319</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE1LxDAQhoMo7rp69Sg9eG2dJG1sjuLnwqog6jVkkykb6ceStAv-e1O6oBdPwzDPDPM-hJxTyCiAuGp2HjMqpcwYFeyAzCnIIpWcykMyB2AiZaVgM3ISwhcApYVkx2RGIS9KyeScvCxb2zXYb7RxbRqbwaBN7lzoB7_WrcGQuDb5dHXdDSF5dsZ3xnkz1Lp3XTvO-g0mb7pPljUOzSk5qnQd8GxfF-Tj4f799ildvT4ub29WqeFC9inqHLQQhktALijHSnNeWKZByJzSCvJ1WWrLsDRM6woFFFIKiJA018ICX5Bsuhv_CcFjpbbeNdp_KwpqFKNGMWoUo0YxceFiWtgO6wbtH3wyEYHLPaCD0XXlY3gXfjkpeJkXESsnDGO6nUOvgnEYPVnn0fTKdu6_F34AbMd_Og</recordid><startdate>19990901</startdate><enddate>19990901</enddate><creator>Ruh, Joachim</creator><creator>Schmidt, Eduard</creator><creator>Vogel, Frank</creator><creator>Klar, Ernst</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>19990901</creationdate><title>Indomethacin-Induced Disturbances in Villous Microcirculation in the Rat Ileum</title><author>Ruh, Joachim ; Schmidt, Eduard ; Vogel, Frank ; Klar, Ernst</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c369t-ea40a66c390e3613efa335d2a069411f04b88ad2e8c2aafe6059960a339c76d03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Animals</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - toxicity</topic><topic>Arterioles - drug effects</topic><topic>Arterioles - pathology</topic><topic>Arterioles - physiopathology</topic><topic>Biological and medical sciences</topic><topic>Blood Flow Velocity - drug effects</topic><topic>Drug toxicity and drugs side effects treatment</topic><topic>Humans</topic><topic>Ileum - blood supply</topic><topic>Ileum - drug effects</topic><topic>indomethacin</topic><topic>Indomethacin - toxicity</topic><topic>Inflammation - chemically induced</topic><topic>Inflammation - pathology</topic><topic>Intestinal Mucosa - blood supply</topic><topic>Intestinal Mucosa - drug effects</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microcirculation - drug effects</topic><topic>Pharmacology. Drug treatments</topic><topic>rat small intestine</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Toxicity: digestive system</topic><topic>villous microcirculation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ruh, Joachim</creatorcontrib><creatorcontrib>Schmidt, Eduard</creatorcontrib><creatorcontrib>Vogel, Frank</creatorcontrib><creatorcontrib>Klar, Ernst</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Microvascular research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ruh, Joachim</au><au>Schmidt, Eduard</au><au>Vogel, Frank</au><au>Klar, Ernst</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Indomethacin-Induced Disturbances in Villous Microcirculation in the Rat Ileum</atitle><jtitle>Microvascular research</jtitle><addtitle>Microvasc Res</addtitle><date>1999-09-01</date><risdate>1999</risdate><volume>58</volume><issue>2</issue><spage>137</spage><epage>143</epage><pages>137-143</pages><issn>0026-2862</issn><eissn>1095-9319</eissn><coden>MIVRA6</coden><abstract>Indomethacin is a widely used nonsteroidal antiphlogistic compound used—among others—for the treatment of rheumatoid arthritis in humans. Common side effects of indomethacin in the gastrointestinal tract include ulcerative lesions and petechial bleeding in the mucosa. In the rat, oral intake of indomethacin induces ulcerations in the mucosa of the stomach and, if administered systemically, edema, petechial bleeding, and ulcerations in the small intestine. In order to determine if systemic administration of indomethacin may induce changes in villous perfusion, we assessed the effect of indomethacin on erythrocyte velocity and the diameter of the main arteriole in the villi of the rat ileum. We found that indomethacin led to a significant decrease in mean arteriolar blood flow (6.3 ± 0.8 vs 5.0 ± 1.2 nl/min, means ± SD) 7 days after administration. Mean diameter of the main arteriole remained unchanged (control, 7.8 ± 0.8 vs indomethacin, 7.0 ± 0.9 μm). In conclusion, systemic application of indomethacin leads to a decrease in blood supply to the mucosa. We previously found an increase in villous perfusion when assessed 24 h after administration of indomethacin, accompanied by an increase in arteriolar diameter of the main arteriole. In summary, different regimens of application of indomethacin lead to varying observations in microcirculatory parameters in single villi. Further studies are required to identify the underlying mechanisms.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>10458929</pmid><doi>10.1006/mvre.1999.2162</doi><tpages>7</tpages></addata></record> |
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| subjects | Animals Anti-Inflammatory Agents, Non-Steroidal - toxicity Arterioles - drug effects Arterioles - pathology Arterioles - physiopathology Biological and medical sciences Blood Flow Velocity - drug effects Drug toxicity and drugs side effects treatment Humans Ileum - blood supply Ileum - drug effects indomethacin Indomethacin - toxicity Inflammation - chemically induced Inflammation - pathology Intestinal Mucosa - blood supply Intestinal Mucosa - drug effects Male Medical sciences Microcirculation - drug effects Pharmacology. Drug treatments rat small intestine Rats Rats, Sprague-Dawley Toxicity: digestive system villous microcirculation |
| title | Indomethacin-Induced Disturbances in Villous Microcirculation in the Rat Ileum |
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