Role of PKC in the Late Phase of Microvascular Protection Induced by Preconditioning

Introduction. We hypothesized that the late phase of microvascular protection induced by ischemic preconditioning or by adenosine is protein kinase C (PKC) dependent. Materials and methods. The cremaster muscle of male Sprague–Dawley rats underwent 45 min of ischemic preconditioning and, 24 h later,...

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Veröffentlicht in:	The Journal of surgical research 2002-07, Vol.106 (1), p.166-172
Hauptverfasser:	Wang, Wei Z., Stepheson, Linda L., Anderson, Gary L., Miller, Frederick N., Khiabani, Kayvan T., Zamboni, Willarm A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine - pharmacology Animals Arterioles - enzymology Biological and medical sciences Capillaries - enzymology Carcinogens - pharmacology Endothelium, Vascular - enzymology ischemia/reperfusion injury Ischemic Preconditioning late preconditioning Male Medical sciences microcirculation Microcirculation - drug effects Microcirculation - physiology Muscle, Skeletal - blood supply Muscle, Skeletal - metabolism Nitric Oxide - metabolism Protein Kinase C - metabolism Rats Rats, Sprague-Dawley Reperfusion Injury - metabolism skeletal muscle Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Tetradecanoylphorbol Acetate - pharmacology Vascular surgery: aorta, extremities, vena cava. Surgery of the lymphatic vessels vasospasm
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