Blockade by Polyunsaturated n-3 Fatty Acids of Endotoxin-Induced Monocytic Tissue Factor Activation Is Mediated by the Depressed Receptor Expression in THP-1 Cells

Background.Monocytic hypercoagulation often occurs in inflammatory conditions. We have previously reported that polyunsaturated n-3 fatty acids (n-3 FA) including eicosapentaenoic acid (20:5) and docosahexaenoic acid (22:6) prevent the activation of monocytic tissue factor (TF) induced by bacterial...

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Veröffentlicht in:	The Journal of surgical research 1999-12, Vol.87 (2), p.217-224
Hauptverfasser:	Chu, Arthur J., Walton, Melissa A., Prasad, Jai K., Seto, Anne
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacterial diseases Bacterial sepsis Biological and medical sciences CD11 Antigens - analysis CD14 endotoxin Fatty Acids, Omega-3 - pharmacology Human bacterial diseases Humans Infectious diseases Lipopolysaccharide Receptors - analysis Lipopolysaccharide Receptors - drug effects Lipopolysaccharides - toxicity Medical sciences Miscellaneous monocytes Monocytes - drug effects Monocytes - metabolism n-3 fatty acid Nitric Oxide - biosynthesis Pharmacology. Drug treatments sepsis Thromboplastin - biosynthesis tissue factor Tumor Cells, Cultured Tumor Necrosis Factor-alpha - biosynthesis
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