Topical prostaglandin E2 and isoproterenol reduce bile acid-induced gastric mucosal injury in shocked rats
In shocked animals, topical application of bile acids at low pH to gastric mucosa results in gross mucosal injury. Both systemic prostaglandins and isoproterenol reduce this injury, but side effects may limit their clinical usefulness. The purpose of this study was to determine the effect of topical...
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| Veröffentlicht in: | The Journal of surgical research 1994-02, Vol.56 (2), p.184-191 |
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| creator | MERCER, D. W KIRSHNER, M. S RITCHIE, W. P DEMPSEY, D. T |
| description | In shocked animals, topical application of bile acids at low pH to gastric mucosa results in gross mucosal injury. Both systemic prostaglandins and isoproterenol reduce this injury, but side effects may limit their clinical usefulness. The purpose of this study was to determine the effect of topical pretreatment with isoproterenol and prostaglandin E2 on gastric mucosal injury induced by low concentrations of bile acid in shocked and normotensive rats. Mucosal injury was assessed by measuring net transmucosal ion fluxes (H+,K+) and luminal accumulation of DNA (DNAE), a sensitive and specific indicator of gastric mucosal cell exfoliation. In this model of mucosal injury, pretreatment with prostaglandin E2 or isoproterenol significantly and dose dependently decreased luminal hydrogen loss, potassium gain, and DNA accumulation in both shocked and normotensive animals. Thus, both topical prostaglandin E2 and isoproterenol reduce gastric mucosal injury caused by low concentrations of bile acid in shocked and normotensive rats, findings corroborated by histology. These findings provide a physiologic basis for the possible use of these agents as prophylaxis or treatment of stress gastritis and gastroduodenal ulcer in the critically ill patient. |
| doi_str_mv | 10.1006/jsre.1994.1030 |
| format | Article |
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W ; KIRSHNER, M. S ; RITCHIE, W. P ; DEMPSEY, D. T</creator><creatorcontrib>MERCER, D. W ; KIRSHNER, M. S ; RITCHIE, W. P ; DEMPSEY, D. T</creatorcontrib><description>In shocked animals, topical application of bile acids at low pH to gastric mucosa results in gross mucosal injury. Both systemic prostaglandins and isoproterenol reduce this injury, but side effects may limit their clinical usefulness. The purpose of this study was to determine the effect of topical pretreatment with isoproterenol and prostaglandin E2 on gastric mucosal injury induced by low concentrations of bile acid in shocked and normotensive rats. Mucosal injury was assessed by measuring net transmucosal ion fluxes (H+,K+) and luminal accumulation of DNA (DNAE), a sensitive and specific indicator of gastric mucosal cell exfoliation. In this model of mucosal injury, pretreatment with prostaglandin E2 or isoproterenol significantly and dose dependently decreased luminal hydrogen loss, potassium gain, and DNA accumulation in both shocked and normotensive animals. Thus, both topical prostaglandin E2 and isoproterenol reduce gastric mucosal injury caused by low concentrations of bile acid in shocked and normotensive rats, findings corroborated by histology. These findings provide a physiologic basis for the possible use of these agents as prophylaxis or treatment of stress gastritis and gastroduodenal ulcer in the critically ill patient.</description><identifier>ISSN: 0022-4804</identifier><identifier>EISSN: 1095-8673</identifier><identifier>DOI: 10.1006/jsre.1994.1030</identifier><identifier>PMID: 8121176</identifier><identifier>CODEN: JSGRA2</identifier><language>eng</language><publisher>New York, NY: Elsevier</publisher><subject>Administration, Topical ; Animals ; Bile Acids and Salts ; Biological and medical sciences ; Digestive system ; Dinoprostone - administration & dosage ; Dinoprostone - therapeutic use ; DNA - metabolism ; Gastric Mucosa - metabolism ; Gastric Mucosa - pathology ; Hydrogen - metabolism ; Isoproterenol - administration & dosage ; Isoproterenol - therapeutic use ; Medical sciences ; Pharmacology. Drug treatments ; Potassium - metabolism ; Rats ; Rats, Sprague-Dawley ; Shock, Hemorrhagic - complications ; Stomach Diseases - chemically induced ; Stomach Diseases - etiology ; Stomach Diseases - pathology ; Taurocholic Acid</subject><ispartof>The Journal of surgical research, 1994-02, Vol.56 (2), p.184-191</ispartof><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c300t-93d9ccfbf67cfeb53740a0f116d8cffacc99a094e84be45f9323e6c885384aa73</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4053209$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8121176$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MERCER, D. W</creatorcontrib><creatorcontrib>KIRSHNER, M. S</creatorcontrib><creatorcontrib>RITCHIE, W. P</creatorcontrib><creatorcontrib>DEMPSEY, D. T</creatorcontrib><title>Topical prostaglandin E2 and isoproterenol reduce bile acid-induced gastric mucosal injury in shocked rats</title><title>The Journal of surgical research</title><addtitle>J Surg Res</addtitle><description>In shocked animals, topical application of bile acids at low pH to gastric mucosa results in gross mucosal injury. Both systemic prostaglandins and isoproterenol reduce this injury, but side effects may limit their clinical usefulness. The purpose of this study was to determine the effect of topical pretreatment with isoproterenol and prostaglandin E2 on gastric mucosal injury induced by low concentrations of bile acid in shocked and normotensive rats. Mucosal injury was assessed by measuring net transmucosal ion fluxes (H+,K+) and luminal accumulation of DNA (DNAE), a sensitive and specific indicator of gastric mucosal cell exfoliation. In this model of mucosal injury, pretreatment with prostaglandin E2 or isoproterenol significantly and dose dependently decreased luminal hydrogen loss, potassium gain, and DNA accumulation in both shocked and normotensive animals. Thus, both topical prostaglandin E2 and isoproterenol reduce gastric mucosal injury caused by low concentrations of bile acid in shocked and normotensive rats, findings corroborated by histology. These findings provide a physiologic basis for the possible use of these agents as prophylaxis or treatment of stress gastritis and gastroduodenal ulcer in the critically ill patient.</description><subject>Administration, Topical</subject><subject>Animals</subject><subject>Bile Acids and Salts</subject><subject>Biological and medical sciences</subject><subject>Digestive system</subject><subject>Dinoprostone - administration & dosage</subject><subject>Dinoprostone - therapeutic use</subject><subject>DNA - metabolism</subject><subject>Gastric Mucosa - metabolism</subject><subject>Gastric Mucosa - pathology</subject><subject>Hydrogen - metabolism</subject><subject>Isoproterenol - administration & dosage</subject><subject>Isoproterenol - therapeutic use</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Potassium - metabolism</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Shock, Hemorrhagic - complications</subject><subject>Stomach Diseases - chemically induced</subject><subject>Stomach Diseases - etiology</subject><subject>Stomach Diseases - pathology</subject><subject>Taurocholic Acid</subject><issn>0022-4804</issn><issn>1095-8673</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kDtPwzAUhS0EKqWwsiF5YE25jp3EHlHFS6rEUubIubGLQ5pEdjL03-OoVaf7OudI9yPkkcGaAeQvTfBmzZQSceRwRZYMVJbIvODXZAmQpomQIG7JXQgNxFkVfEEWkqWMFfmSNLt-cKhbOvg-jHrf6q52HX1LaWyoC33cj8abrm-pN_WEhlauNVSjqxPXzYua7nUYvUN6mLAPMct1zeSPsdDw2-NfVHg9hntyY3UbzMO5rsjP-9tu85lsvz--Nq_bBDnAmCheK0Rb2bxAa6qMFwI0WMbyWqK1GlEpDUoYKSojMqt4yk2OUmZcCq0LviLrUy7GlyIdWw7eHbQ_lgzKmVk5MytnZuXMLBqeToZhqg6mvsjPkOL9-XzXIaKyXnfowkUmIOMpKP4PnJt3Ig</recordid><startdate>199402</startdate><enddate>199402</enddate><creator>MERCER, D. 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T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c300t-93d9ccfbf67cfeb53740a0f116d8cffacc99a094e84be45f9323e6c885384aa73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Administration, Topical</topic><topic>Animals</topic><topic>Bile Acids and Salts</topic><topic>Biological and medical sciences</topic><topic>Digestive system</topic><topic>Dinoprostone - administration & dosage</topic><topic>Dinoprostone - therapeutic use</topic><topic>DNA - metabolism</topic><topic>Gastric Mucosa - metabolism</topic><topic>Gastric Mucosa - pathology</topic><topic>Hydrogen - metabolism</topic><topic>Isoproterenol - administration & dosage</topic><topic>Isoproterenol - therapeutic use</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>Potassium - metabolism</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Shock, Hemorrhagic - complications</topic><topic>Stomach Diseases - chemically induced</topic><topic>Stomach Diseases - etiology</topic><topic>Stomach Diseases - pathology</topic><topic>Taurocholic Acid</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MERCER, D. W</creatorcontrib><creatorcontrib>KIRSHNER, M. S</creatorcontrib><creatorcontrib>RITCHIE, W. P</creatorcontrib><creatorcontrib>DEMPSEY, D. 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T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Topical prostaglandin E2 and isoproterenol reduce bile acid-induced gastric mucosal injury in shocked rats</atitle><jtitle>The Journal of surgical research</jtitle><addtitle>J Surg Res</addtitle><date>1994-02</date><risdate>1994</risdate><volume>56</volume><issue>2</issue><spage>184</spage><epage>191</epage><pages>184-191</pages><issn>0022-4804</issn><eissn>1095-8673</eissn><coden>JSGRA2</coden><abstract>In shocked animals, topical application of bile acids at low pH to gastric mucosa results in gross mucosal injury. Both systemic prostaglandins and isoproterenol reduce this injury, but side effects may limit their clinical usefulness. The purpose of this study was to determine the effect of topical pretreatment with isoproterenol and prostaglandin E2 on gastric mucosal injury induced by low concentrations of bile acid in shocked and normotensive rats. Mucosal injury was assessed by measuring net transmucosal ion fluxes (H+,K+) and luminal accumulation of DNA (DNAE), a sensitive and specific indicator of gastric mucosal cell exfoliation. In this model of mucosal injury, pretreatment with prostaglandin E2 or isoproterenol significantly and dose dependently decreased luminal hydrogen loss, potassium gain, and DNA accumulation in both shocked and normotensive animals. Thus, both topical prostaglandin E2 and isoproterenol reduce gastric mucosal injury caused by low concentrations of bile acid in shocked and normotensive rats, findings corroborated by histology. These findings provide a physiologic basis for the possible use of these agents as prophylaxis or treatment of stress gastritis and gastroduodenal ulcer in the critically ill patient.</abstract><cop>New York, NY</cop><pub>Elsevier</pub><pmid>8121176</pmid><doi>10.1006/jsre.1994.1030</doi><tpages>8</tpages></addata></record> |
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| ispartof | The Journal of surgical research, 1994-02, Vol.56 (2), p.184-191 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Administration, Topical Animals Bile Acids and Salts Biological and medical sciences Digestive system Dinoprostone - administration & dosage Dinoprostone - therapeutic use DNA - metabolism Gastric Mucosa - metabolism Gastric Mucosa - pathology Hydrogen - metabolism Isoproterenol - administration & dosage Isoproterenol - therapeutic use Medical sciences Pharmacology. Drug treatments Potassium - metabolism Rats Rats, Sprague-Dawley Shock, Hemorrhagic - complications Stomach Diseases - chemically induced Stomach Diseases - etiology Stomach Diseases - pathology Taurocholic Acid |
| title | Topical prostaglandin E2 and isoproterenol reduce bile acid-induced gastric mucosal injury in shocked rats |
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