Dopamine Oxidation Generates an Oxidative Stress Mediated by Dopamine Semiquinone and Unrelated to Reactive Oxygen Species

Dopamine (100μm, 10–30 min) inhibits/inactivates the MgATP-dependent generation of a transmembrane proton electrochemical gradient in chromaffin granule ghosts. The dopamine dependent inhibition was enhanced by adding soluble dopamineβ-monooxygenase (DBM, 0.2 U/ml) and completely prevented by ascorb...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of molecular and cellular cardiology 1997-06, Vol.29 (6), p.1731-1738
Hauptverfasser:	Terland, Ole, Flatmark, Torgeir, Tangerås, Arild, Grønberg, Martin
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenal medulla (bovine) Animals Ascorbic Acid - pharmacology Benzoquinones - metabolism Catalase - pharmacology Cattle Chromaffin Cells - drug effects Chromaffin Cells - metabolism Chromaffin granules DDT - pharmacology Dopamine Dopamine - metabolism Dopamine - pharmacology Dopamine semiquinone Enzyme Inhibitors - pharmacology Ferricyanides - metabolism Free radicals Fusaric Acid - pharmacology H+-ATPase Lipid Peroxidation Malondialdehyde - metabolism Oxidative stress Oxidative Stress - physiology Proton Pump Inhibitors Proton-Translocating ATPases - drug effects Proton-Translocating ATPases - metabolism Reactive Oxygen Species - metabolism Superoxide Dismutase - pharmacology Vacuoles - drug effects Vacuoles - enzymology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!