Acute and Chronic Effects of Adriamycin on Fatty Acid Oxidation in Isolated Cardiac Myocytes

This study was designed to determine if acute (in vitro) or chronic (in vivo) adriamycin inhibits cardiac fatty acid oxidation and if so at what sites in the fatty acid oxidation pathway. In addition, the role ofl-carnitine in reversing or preventing this effect was examined. We determined the effec...

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Veröffentlicht in:	Journal of molecular and cellular cardiology 1997-02, Vol.29 (2), p.789-797
Hauptverfasser:	Abdel-aleem, Salah, El-Merzabani, Mahmoud M., Sayed-Ahmed, Mohamed, Taylor, Doris A., Lowe, James E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adriamycin Animals Antibiotics, Antineoplastic - pharmacology Caprylates - metabolism Cardiotoxicity Carnitine - pharmacology Carnitine O-Palmitoyltransferase - drug effects Carnitine O-Palmitoyltransferase - metabolism Cells, Cultured Dose-Response Relationship, Drug Doxorubicin - adverse effects Fatty acid oxidation Fatty Acids - metabolism Glucose - metabolism Heart - drug effects l-Carnitine Male Mitochondria, Heart - metabolism Myocardium - cytology Myocardium - metabolism Oxidation-Reduction Palmitic Acid - metabolism Pyruvic Acid - metabolism Rats Rats, Sprague-Dawley
Online-Zugang:	Volltext
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