Genetic interaction between yeast Saccharomyces cerevisiae release factors and the decoding region of 18 S rRNA

Functional and structural similarities between tRNA and eukaryotic class 1 release factors (eRF1) described previously, provide evidence for the molecular mimicry concept. This concept is supported here by the demonstration of a genetic interaction between eRF1 and the decoding region of the ribosom...

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Veröffentlicht in:	Journal of molecular biology 2001-01, Vol.305 (4), p.715-727
Hauptverfasser:	Velichutina, Irina V., Hong, Joo Yun, Mesecar, Andrew D., Chernoff, Yury O., Liebman, Susan W.
Format:	Artikel
Sprache:	eng
Schlagworte:	[PSI +] prion Anti-Bacterial Agents - metabolism Anti-Bacterial Agents - pharmacology Anticodon - chemistry Anticodon - genetics Base Pairing Base Sequence Codon, Terminator - genetics Drug Resistance, Microbial Frameshift Mutation - genetics Fungal Proteins - chemistry Fungal Proteins - genetics Fungal Proteins - metabolism Genes, Fungal - genetics Genes, Lethal - genetics paromomycin Paromomycin - metabolism Paromomycin - pharmacology Peptide Termination Factors - biosynthesis Peptide Termination Factors - chemistry Peptide Termination Factors - genetics Peptide Termination Factors - metabolism Protein Biosynthesis - drug effects ribosome Ribosomes - metabolism RNA, Ribosomal, 18S - chemistry RNA, Ribosomal, 18S - genetics RNA, Ribosomal, 18S - metabolism rRNA Saccharomyces cerevisiae - cytology Saccharomyces cerevisiae - drug effects Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism Suppression, Genetic - genetics translation
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