X-ray Structure of a Monomeric Cyclophilin A-Cyclosporin A Crystal Complex at 2·1 Å Resolution

The crystal structure of a complex between recombinant human cyclophilin A (Cyp) and cyclosporin A (CsA) has been determined from a novel orthorhombic crystal form that contains only one monomer of complex per asymmetric unit rather than five in the previously determined tetragonal structure. The st...

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Veröffentlicht in:	Journal of molecular biology 1993-12, Vol.234 (4), p.1119-1130
Hauptverfasser:	Mikol, Vincent, Kallen, Jörg, Pflügl, Gaston, Walkinshaw, Malcolm D.
Format:	Artikel
Sprache:	eng
Schlagworte:	cyclophilin cyclosporin immunosuppression protein crystallography protein-peptide interactions
Online-Zugang:	Volltext
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