The Time Course and Characterization of Mercuric Chloride-Induced Immunopathology in the Brown Norway Rat

Mercuric chloride (HgCl2) induces an autoimmune syndrome in the Brown Norway (BN) rat which includes widespread tissue injury. There is necrotizing leucocytoclastic vasculitis in the gut with maximal injury occurring 2 weeks after the start of HgCl2injections. There is evidence that disease is drive...

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Veröffentlicht in:	Journal of autoimmunity 1995-04, Vol.8 (2), p.193-208
Hauptverfasser:	Qasim, Faieza J., Thiru, Sathia, Mathieson, Peter W., Oliveira, David B.G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibody Specificity Autoantibodies - biosynthesis Autoantibodies - immunology Autoimmune Diseases - chemically induced Autoimmune Diseases - genetics Autoimmune Diseases - immunology Autoimmune Diseases - pathology Biological and medical sciences Cecum - pathology Disease Progression Experimental and animal immunopathology. Animal models Female Immunopathology Intestinal Mucosa - pathology Lung - pathology Lymph Nodes - pathology Lymphocyte Count Lymphoproliferative Disorders - chemically induced Lymphoproliferative Disorders - genetics Lymphoproliferative Disorders - immunology Lymphoproliferative Disorders - pathology Male Medical sciences Mercuric Chloride - toxicity Neutrophils - immunology Neutrophils - pathology Peroxidase - immunology Rats Rats, Inbred BN - immunology Skin - pathology Spleen - pathology T-Lymphocyte Subsets - immunology Th1 Cells - immunology Th2 Cells - immunology Time Factors Vasculitis, Leukocytoclastic, Cutaneous - chemically induced Vasculitis, Leukocytoclastic, Cutaneous - genetics Vasculitis, Leukocytoclastic, Cutaneous - immunology Vasculitis, Leukocytoclastic, Cutaneous - pathology
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