Synergistic Induction of Apoptosis by the Combination of TRAIL and Chemotherapy in Chemoresistant Ovarian Cancer Cells

Objectives. The aim of this study was to investigate whether TNF-related apoptosis-inducing ligand (TRAIL) alone or in combination with chemotherapy could induce apoptosis in ovarian cancer cells resistant to chemotherapy. Methods. Twelve chemoresistant epithelial cancer cell lines were treated with...

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Veröffentlicht in:	Gynecologic oncology 2001-06, Vol.81 (3), p.380-390
Hauptverfasser:	Cuello, Mauricio, Ettenberg, Seth A., Nau, Marion M., Lipkowitz, Stan
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - administration & dosage Antineoplastic Agents - pharmacology Antineoplastic Combined Chemotherapy Protocols - pharmacology apoptosis Apoptosis - drug effects Apoptosis - physiology Apoptosis Regulatory Proteins Biological and medical sciences Caspase 3 Caspases - metabolism Cell Division - drug effects chemotherapy Cisplatin - administration & dosage Cisplatin - pharmacology Doxorubicin - administration & dosage Doxorubicin - pharmacology Drug Resistance, Multiple Drug Resistance, Neoplasm Drug Synergism Female Female genital diseases Gynecology. Andrology. Obstetrics Humans Medical sciences Membrane Glycoproteins - administration & dosage Membrane Glycoproteins - pharmacology ovarian cell line Ovarian Neoplasms - drug therapy Ovarian Neoplasms - metabolism Ovarian Neoplasms - pathology Paclitaxel - administration & dosage Paclitaxel - pharmacology Poly(ADP-ribose) Polymerases - metabolism Receptors, TNF-Related Apoptosis-Inducing Ligand Receptors, Tumor Necrosis Factor - biosynthesis Receptors, Tumor Necrosis Factor - genetics Recombinant Fusion Proteins - administration & dosage Recombinant Fusion Proteins - pharmacology RNA, Messenger - biosynthesis RNA, Messenger - genetics TNF-Related Apoptosis-Inducing Ligand TRAIL Tumor Cells, Cultured Tumor Necrosis Factor-alpha - administration & dosage Tumor Necrosis Factor-alpha - pharmacology Tumors
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