Genetic Dissection of “OLETF,” a Rat Model for Non-Insulin-Dependent Diabetes Mellitus: Quantitative Trait Locus Analysis of (OLETF × BN) × OLETF
To identify genetic determinants relevant to non-insulin-dependent diabetes mellitus (NIDDM), we performed a genome-wide analysis for quantitative trait loci (QTLs) using 359 backcross progeny of the Otsuka Long-Evans Tokushima Fatty (OLETF) rat. The OLETF strain is a well-studied animal model of ob...
Gespeichert in:
| Veröffentlicht in: | Genomics (San Diego, Calif.) Calif.), 1999-06, Vol.58 (3), p.233-239 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 239 |
|---|---|
| container_issue | 3 |
| container_start_page | 233 |
| container_title | Genomics (San Diego, Calif.) |
| container_volume | 58 |
| creator | Watanabe, Takeshi K. Okuno, Shiro Oga, Keiko Mizoguchi-Miyakita, Ayako Tsuji, Atsushi Yamasaki, Yuki Hishigaki, Haretsugu Kanemoto, Naohide Takagi, Toshihisa Takahashi, Ei-ichi Irie, Yasuo Nakamura, Yusuke Tanigami, Akira |
| description | To identify genetic determinants relevant to non-insulin-dependent diabetes mellitus (NIDDM), we performed a genome-wide analysis for quantitative trait loci (QTLs) using 359 backcross progeny of the Otsuka Long-Evans Tokushima Fatty (OLETF) rat. The OLETF strain is a well-studied animal model of obese NIDDM, with features of hyperinsulinemia, hyperglycemia, insulin resistance, and abundant abdominal fat. Our extensive genomic scanning with 218 markers revealed nine significant QTLs, including a strong determinant of obesity on chromosome 1 (Dmo1: LOD = 13.99, for body weight). Two highly significant QTLs for glucose homeostasis were found, one on chromosome 1 (Dmo4 LOD = 7.16, for postprandial glucose level) and the other on chromosome X (Dmo11/Odb1: LOD = 7.81, for postprandial glucose level). These data are comparable to results of our previous studies of the OLETF rat. |
| doi_str_mv | 10.1006/geno.1999.5789 |
| format | Article |
| fullrecord | <record><control><sourceid>elsevier_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1006_geno_1999_5789</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0888754399957890</els_id><sourcerecordid>S0888754399957890</sourcerecordid><originalsourceid>FETCH-LOGICAL-c1990-341633f4a059eae87ea6a80ddcc22b0632c9702f694e8ca4523b3637130fe8943</originalsourceid><addsrcrecordid>eNp1kLtOwzAYhS0EEqWwMnsEiQQnzsVmg96o1ItAZY5c5w8yCnYVO5W69S26wNPwJn0SkpaV6egM55z__xC6DogfEJLcv4M2fsA59-OU8RPUCQjjHkui5BR1CGPMS-OInqMLaz8IIZyysIN2I9DglMR9ZS1Ip4zGpsD77dd8MlgM7_bbbyzwq3B4anIocWEqPDPaG2tbl0p7fViBzkG7pkAswYHFUyhL5Wr7gF9qoZ1ywqk14EUllMMTI2uLH7UoN1bZdurmMIR_dvhpdtvKwV-is0KUFq7-tIvehoNF79mbzEfj3uPEk82nxKNRkFBaRILEHASwFEQiGMlzKcNwSRIaSp6SsEh4BEyKKA7pkiY0DSgpgPGIdpF_7JWVsbaCIltV6lNUmywgWYs1a7FmLdasxdoE2DEAzVVrBVVmpQItIVdVwy_Ljfov-guZaICZ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Genetic Dissection of “OLETF,” a Rat Model for Non-Insulin-Dependent Diabetes Mellitus: Quantitative Trait Locus Analysis of (OLETF × BN) × OLETF</title><source>Elsevier ScienceDirect Journals</source><creator>Watanabe, Takeshi K. ; Okuno, Shiro ; Oga, Keiko ; Mizoguchi-Miyakita, Ayako ; Tsuji, Atsushi ; Yamasaki, Yuki ; Hishigaki, Haretsugu ; Kanemoto, Naohide ; Takagi, Toshihisa ; Takahashi, Ei-ichi ; Irie, Yasuo ; Nakamura, Yusuke ; Tanigami, Akira</creator><creatorcontrib>Watanabe, Takeshi K. ; Okuno, Shiro ; Oga, Keiko ; Mizoguchi-Miyakita, Ayako ; Tsuji, Atsushi ; Yamasaki, Yuki ; Hishigaki, Haretsugu ; Kanemoto, Naohide ; Takagi, Toshihisa ; Takahashi, Ei-ichi ; Irie, Yasuo ; Nakamura, Yusuke ; Tanigami, Akira</creatorcontrib><description>To identify genetic determinants relevant to non-insulin-dependent diabetes mellitus (NIDDM), we performed a genome-wide analysis for quantitative trait loci (QTLs) using 359 backcross progeny of the Otsuka Long-Evans Tokushima Fatty (OLETF) rat. The OLETF strain is a well-studied animal model of obese NIDDM, with features of hyperinsulinemia, hyperglycemia, insulin resistance, and abundant abdominal fat. Our extensive genomic scanning with 218 markers revealed nine significant QTLs, including a strong determinant of obesity on chromosome 1 (Dmo1: LOD = 13.99, for body weight). Two highly significant QTLs for glucose homeostasis were found, one on chromosome 1 (Dmo4 LOD = 7.16, for postprandial glucose level) and the other on chromosome X (Dmo11/Odb1: LOD = 7.81, for postprandial glucose level). These data are comparable to results of our previous studies of the OLETF rat.</description><identifier>ISSN: 0888-7543</identifier><identifier>EISSN: 1089-8646</identifier><identifier>DOI: 10.1006/geno.1999.5789</identifier><language>eng</language><publisher>Elsevier Inc</publisher><ispartof>Genomics (San Diego, Calif.), 1999-06, Vol.58 (3), p.233-239</ispartof><rights>1999 Academic Press</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c1990-341633f4a059eae87ea6a80ddcc22b0632c9702f694e8ca4523b3637130fe8943</citedby><cites>FETCH-LOGICAL-c1990-341633f4a059eae87ea6a80ddcc22b0632c9702f694e8ca4523b3637130fe8943</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1006/geno.1999.5789$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,45974</link.rule.ids></links><search><creatorcontrib>Watanabe, Takeshi K.</creatorcontrib><creatorcontrib>Okuno, Shiro</creatorcontrib><creatorcontrib>Oga, Keiko</creatorcontrib><creatorcontrib>Mizoguchi-Miyakita, Ayako</creatorcontrib><creatorcontrib>Tsuji, Atsushi</creatorcontrib><creatorcontrib>Yamasaki, Yuki</creatorcontrib><creatorcontrib>Hishigaki, Haretsugu</creatorcontrib><creatorcontrib>Kanemoto, Naohide</creatorcontrib><creatorcontrib>Takagi, Toshihisa</creatorcontrib><creatorcontrib>Takahashi, Ei-ichi</creatorcontrib><creatorcontrib>Irie, Yasuo</creatorcontrib><creatorcontrib>Nakamura, Yusuke</creatorcontrib><creatorcontrib>Tanigami, Akira</creatorcontrib><title>Genetic Dissection of “OLETF,” a Rat Model for Non-Insulin-Dependent Diabetes Mellitus: Quantitative Trait Locus Analysis of (OLETF × BN) × OLETF</title><title>Genomics (San Diego, Calif.)</title><description>To identify genetic determinants relevant to non-insulin-dependent diabetes mellitus (NIDDM), we performed a genome-wide analysis for quantitative trait loci (QTLs) using 359 backcross progeny of the Otsuka Long-Evans Tokushima Fatty (OLETF) rat. The OLETF strain is a well-studied animal model of obese NIDDM, with features of hyperinsulinemia, hyperglycemia, insulin resistance, and abundant abdominal fat. Our extensive genomic scanning with 218 markers revealed nine significant QTLs, including a strong determinant of obesity on chromosome 1 (Dmo1: LOD = 13.99, for body weight). Two highly significant QTLs for glucose homeostasis were found, one on chromosome 1 (Dmo4 LOD = 7.16, for postprandial glucose level) and the other on chromosome X (Dmo11/Odb1: LOD = 7.81, for postprandial glucose level). These data are comparable to results of our previous studies of the OLETF rat.</description><issn>0888-7543</issn><issn>1089-8646</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><recordid>eNp1kLtOwzAYhS0EEqWwMnsEiQQnzsVmg96o1ItAZY5c5w8yCnYVO5W69S26wNPwJn0SkpaV6egM55z__xC6DogfEJLcv4M2fsA59-OU8RPUCQjjHkui5BR1CGPMS-OInqMLaz8IIZyysIN2I9DglMR9ZS1Ip4zGpsD77dd8MlgM7_bbbyzwq3B4anIocWEqPDPaG2tbl0p7fViBzkG7pkAswYHFUyhL5Wr7gF9qoZ1ywqk14EUllMMTI2uLH7UoN1bZdurmMIR_dvhpdtvKwV-is0KUFq7-tIvehoNF79mbzEfj3uPEk82nxKNRkFBaRILEHASwFEQiGMlzKcNwSRIaSp6SsEh4BEyKKA7pkiY0DSgpgPGIdpF_7JWVsbaCIltV6lNUmywgWYs1a7FmLdasxdoE2DEAzVVrBVVmpQItIVdVwy_Ljfov-guZaICZ</recordid><startdate>199906</startdate><enddate>199906</enddate><creator>Watanabe, Takeshi K.</creator><creator>Okuno, Shiro</creator><creator>Oga, Keiko</creator><creator>Mizoguchi-Miyakita, Ayako</creator><creator>Tsuji, Atsushi</creator><creator>Yamasaki, Yuki</creator><creator>Hishigaki, Haretsugu</creator><creator>Kanemoto, Naohide</creator><creator>Takagi, Toshihisa</creator><creator>Takahashi, Ei-ichi</creator><creator>Irie, Yasuo</creator><creator>Nakamura, Yusuke</creator><creator>Tanigami, Akira</creator><general>Elsevier Inc</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>199906</creationdate><title>Genetic Dissection of “OLETF,” a Rat Model for Non-Insulin-Dependent Diabetes Mellitus: Quantitative Trait Locus Analysis of (OLETF × BN) × OLETF</title><author>Watanabe, Takeshi K. ; Okuno, Shiro ; Oga, Keiko ; Mizoguchi-Miyakita, Ayako ; Tsuji, Atsushi ; Yamasaki, Yuki ; Hishigaki, Haretsugu ; Kanemoto, Naohide ; Takagi, Toshihisa ; Takahashi, Ei-ichi ; Irie, Yasuo ; Nakamura, Yusuke ; Tanigami, Akira</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1990-341633f4a059eae87ea6a80ddcc22b0632c9702f694e8ca4523b3637130fe8943</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Watanabe, Takeshi K.</creatorcontrib><creatorcontrib>Okuno, Shiro</creatorcontrib><creatorcontrib>Oga, Keiko</creatorcontrib><creatorcontrib>Mizoguchi-Miyakita, Ayako</creatorcontrib><creatorcontrib>Tsuji, Atsushi</creatorcontrib><creatorcontrib>Yamasaki, Yuki</creatorcontrib><creatorcontrib>Hishigaki, Haretsugu</creatorcontrib><creatorcontrib>Kanemoto, Naohide</creatorcontrib><creatorcontrib>Takagi, Toshihisa</creatorcontrib><creatorcontrib>Takahashi, Ei-ichi</creatorcontrib><creatorcontrib>Irie, Yasuo</creatorcontrib><creatorcontrib>Nakamura, Yusuke</creatorcontrib><creatorcontrib>Tanigami, Akira</creatorcontrib><collection>CrossRef</collection><jtitle>Genomics (San Diego, Calif.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Watanabe, Takeshi K.</au><au>Okuno, Shiro</au><au>Oga, Keiko</au><au>Mizoguchi-Miyakita, Ayako</au><au>Tsuji, Atsushi</au><au>Yamasaki, Yuki</au><au>Hishigaki, Haretsugu</au><au>Kanemoto, Naohide</au><au>Takagi, Toshihisa</au><au>Takahashi, Ei-ichi</au><au>Irie, Yasuo</au><au>Nakamura, Yusuke</au><au>Tanigami, Akira</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genetic Dissection of “OLETF,” a Rat Model for Non-Insulin-Dependent Diabetes Mellitus: Quantitative Trait Locus Analysis of (OLETF × BN) × OLETF</atitle><jtitle>Genomics (San Diego, Calif.)</jtitle><date>1999-06</date><risdate>1999</risdate><volume>58</volume><issue>3</issue><spage>233</spage><epage>239</epage><pages>233-239</pages><issn>0888-7543</issn><eissn>1089-8646</eissn><abstract>To identify genetic determinants relevant to non-insulin-dependent diabetes mellitus (NIDDM), we performed a genome-wide analysis for quantitative trait loci (QTLs) using 359 backcross progeny of the Otsuka Long-Evans Tokushima Fatty (OLETF) rat. The OLETF strain is a well-studied animal model of obese NIDDM, with features of hyperinsulinemia, hyperglycemia, insulin resistance, and abundant abdominal fat. Our extensive genomic scanning with 218 markers revealed nine significant QTLs, including a strong determinant of obesity on chromosome 1 (Dmo1: LOD = 13.99, for body weight). Two highly significant QTLs for glucose homeostasis were found, one on chromosome 1 (Dmo4 LOD = 7.16, for postprandial glucose level) and the other on chromosome X (Dmo11/Odb1: LOD = 7.81, for postprandial glucose level). These data are comparable to results of our previous studies of the OLETF rat.</abstract><pub>Elsevier Inc</pub><doi>10.1006/geno.1999.5789</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0888-7543 |
| ispartof | Genomics (San Diego, Calif.), 1999-06, Vol.58 (3), p.233-239 |
| issn | 0888-7543 1089-8646 |
| language | eng |
| recordid | cdi_crossref_primary_10_1006_geno_1999_5789 |
| source | Elsevier ScienceDirect Journals |
| title | Genetic Dissection of “OLETF,” a Rat Model for Non-Insulin-Dependent Diabetes Mellitus: Quantitative Trait Locus Analysis of (OLETF × BN) × OLETF |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-22T08%3A15%3A53IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-elsevier_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Genetic%20Dissection%20of%20%E2%80%9COLETF,%E2%80%9D%20a%20Rat%20Model%20for%20Non-Insulin-Dependent%20Diabetes%20Mellitus:%20Quantitative%20Trait%20Locus%20Analysis%20of%20(OLETF%20%C3%97%20BN)%20%C3%97%20OLETF&rft.jtitle=Genomics%20(San%20Diego,%20Calif.)&rft.au=Watanabe,%20Takeshi%20K.&rft.date=1999-06&rft.volume=58&rft.issue=3&rft.spage=233&rft.epage=239&rft.pages=233-239&rft.issn=0888-7543&rft.eissn=1089-8646&rft_id=info:doi/10.1006/geno.1999.5789&rft_dat=%3Celsevier_cross%3ES0888754399957890%3C/elsevier_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rft_els_id=S0888754399957890&rfr_iscdi=true |