Regions of Human Chromosome 2 (2q32–q35) and Mouse Chromosome 1 Show Synteny with the Pufferfish Genome (Fugu rubripes)
We have isolated and sequenced a cosmid clone from the compact genome of the Japanese pufferfish (Fugu rubripes) containing portions of three genes that have the same order as in human. The gene order is microtubule-associated protein (MAP-2), myosin light chain (MYL-1), and carbamoyl phosphate synt...
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| Veröffentlicht in: | Genomics (San Diego, Calif.) Calif.), 1997-10, Vol.45 (1), p.158-167 |
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| container_title | Genomics (San Diego, Calif.) |
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| creator | Schofield, J.Paul Elgar, Greg Greystrong, John Lye, Georgina Deadman, Rebecca Micklem, Gos King, Andrew Brenner, Sydney Vaudin, Mark |
| description | We have isolated and sequenced a cosmid clone from the compact genome of the Japanese pufferfish (Fugu rubripes) containing portions of three genes that have the same order as in human. The gene order is microtubule-associated protein (MAP-2), myosin light chain (MYL-1), and carbamoyl phosphate synthetase (CPS III). The intron–exon organization ofFugu CPS IIIis identical with that of ratCPS I,although the equivalent genomic fragments of rat andFugu CPSspan 87.9 and 21 kb, respectively. This is the first report of a piscineCPS IIIgenomic structure and predicts a close evolutionary link betweenCPS IIIandCPS I.The 8-kb intergenic region betweenMYL-1andCPSgave no clear areas of transcription factor-binding sites by pairwise comparison with shark or ratCPSpromoter regions. However, there was a match with the rat myosin light chain 2 (MLC-2) gene promoter and a MyoD transcription factor-binding site 874 bp upstream of theMYL-1gene. |
| doi_str_mv | 10.1006/geno.1997.4913 |
| format | Article |
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The gene order is microtubule-associated protein (MAP-2), myosin light chain (MYL-1), and carbamoyl phosphate synthetase (CPS III). The intron–exon organization ofFugu CPS IIIis identical with that of ratCPS I,although the equivalent genomic fragments of rat andFugu CPSspan 87.9 and 21 kb, respectively. This is the first report of a piscineCPS IIIgenomic structure and predicts a close evolutionary link betweenCPS IIIandCPS I.The 8-kb intergenic region betweenMYL-1andCPSgave no clear areas of transcription factor-binding sites by pairwise comparison with shark or ratCPSpromoter regions. However, there was a match with the rat myosin light chain 2 (MLC-2) gene promoter and a MyoD transcription factor-binding site 874 bp upstream of theMYL-1gene.</description><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Carbon-Nitrogen Ligases - genetics</subject><subject>Chromosomes, Human, Pair 2</subject><subject>Classical genetics, quantitative genetics, hybrids</subject><subject>Fishes, Poisonous - genetics</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genetics of eukaryotes. Biological and molecular evolution</subject><subject>Genome</subject><subject>Humans</subject><subject>Mice</subject><subject>Microtubule-Associated Proteins - genetics</subject><subject>Molecular Sequence Data</subject><subject>Myosin Light Chains - genetics</subject><subject>Rats</subject><subject>Sequence Homology, Amino Acid</subject><subject>Vertebrata</subject><issn>0888-7543</issn><issn>1089-8646</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kLtOwzAUhi0EgnJZ2ZA8MMCQ4ksS2yOquEkgELBHrn3cGJG42AmoG-_AG_IkpGqFWJjO8H__0TkfQoeUjCkh5dkM2jCmSolxrijfQCNKpMpkmZebaESklJkocr6DdlN6IYQoLtk22lacKy7YCC0eYeZDm3Bw-LpvdIsndQxNSKEBzPAJe-Ps-_PrjRenWLcW34U-wV-G4qc6fOCnRdtBu8AfvqtxVwN-6J2D6Hyq8dVw4kCeXPazHsd-Gv0c0uk-2nL6NcHBeu6h58uL58l1dnt_dTM5v80ML2WXgeOKTnNmVCEK40phQU2FMSBU4YxzlivHBMsplIJZBbrIFdOWWqm1k4zvofFqrYkhpQiumkff6LioKKmWBqulwWppsFoaHApHq8K8nzZgf_G1siE_Xuc6Gf3qom6NT78YI3kuCjFgcoXB8Nu7h1gl46E1YH0E01U2-P8u-AGz7I2_</recordid><startdate>19971001</startdate><enddate>19971001</enddate><creator>Schofield, J.Paul</creator><creator>Elgar, Greg</creator><creator>Greystrong, John</creator><creator>Lye, Georgina</creator><creator>Deadman, Rebecca</creator><creator>Micklem, Gos</creator><creator>King, Andrew</creator><creator>Brenner, Sydney</creator><creator>Vaudin, Mark</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>19971001</creationdate><title>Regions of Human Chromosome 2 (2q32–q35) and Mouse Chromosome 1 Show Synteny with the Pufferfish Genome (Fugu rubripes)</title><author>Schofield, J.Paul ; Elgar, Greg ; Greystrong, John ; Lye, Georgina ; Deadman, Rebecca ; Micklem, Gos ; King, Andrew ; Brenner, Sydney ; Vaudin, Mark</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c368t-ef391b42c9575cf67de9b7cce795fcffd39f27241e672d9ea5492ad1d8aaf823</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Carbon-Nitrogen Ligases - genetics</topic><topic>Chromosomes, Human, Pair 2</topic><topic>Classical genetics, quantitative genetics, hybrids</topic><topic>Fishes, Poisonous - genetics</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genetics of eukaryotes. Biological and molecular evolution</topic><topic>Genome</topic><topic>Humans</topic><topic>Mice</topic><topic>Microtubule-Associated Proteins - genetics</topic><topic>Molecular Sequence Data</topic><topic>Myosin Light Chains - genetics</topic><topic>Rats</topic><topic>Sequence Homology, Amino Acid</topic><topic>Vertebrata</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schofield, J.Paul</creatorcontrib><creatorcontrib>Elgar, Greg</creatorcontrib><creatorcontrib>Greystrong, John</creatorcontrib><creatorcontrib>Lye, Georgina</creatorcontrib><creatorcontrib>Deadman, Rebecca</creatorcontrib><creatorcontrib>Micklem, Gos</creatorcontrib><creatorcontrib>King, Andrew</creatorcontrib><creatorcontrib>Brenner, Sydney</creatorcontrib><creatorcontrib>Vaudin, Mark</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Genomics (San Diego, Calif.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schofield, J.Paul</au><au>Elgar, Greg</au><au>Greystrong, John</au><au>Lye, Georgina</au><au>Deadman, Rebecca</au><au>Micklem, Gos</au><au>King, Andrew</au><au>Brenner, Sydney</au><au>Vaudin, Mark</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Regions of Human Chromosome 2 (2q32–q35) and Mouse Chromosome 1 Show Synteny with the Pufferfish Genome (Fugu rubripes)</atitle><jtitle>Genomics (San Diego, Calif.)</jtitle><addtitle>Genomics</addtitle><date>1997-10-01</date><risdate>1997</risdate><volume>45</volume><issue>1</issue><spage>158</spage><epage>167</epage><pages>158-167</pages><issn>0888-7543</issn><eissn>1089-8646</eissn><abstract>We have isolated and sequenced a cosmid clone from the compact genome of the Japanese pufferfish (Fugu rubripes) containing portions of three genes that have the same order as in human. The gene order is microtubule-associated protein (MAP-2), myosin light chain (MYL-1), and carbamoyl phosphate synthetase (CPS III). The intron–exon organization ofFugu CPS IIIis identical with that of ratCPS I,although the equivalent genomic fragments of rat andFugu CPSspan 87.9 and 21 kb, respectively. This is the first report of a piscineCPS IIIgenomic structure and predicts a close evolutionary link betweenCPS IIIandCPS I.The 8-kb intergenic region betweenMYL-1andCPSgave no clear areas of transcription factor-binding sites by pairwise comparison with shark or ratCPSpromoter regions. However, there was a match with the rat myosin light chain 2 (MLC-2) gene promoter and a MyoD transcription factor-binding site 874 bp upstream of theMYL-1gene.</abstract><cop>San Diego, CA</cop><pub>Elsevier Inc</pub><pmid>9339372</pmid><doi>10.1006/geno.1997.4913</doi><tpages>10</tpages></addata></record> |
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| ispartof | Genomics (San Diego, Calif.), 1997-10, Vol.45 (1), p.158-167 |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Amino Acid Sequence Animals Biological and medical sciences Carbon-Nitrogen Ligases - genetics Chromosomes, Human, Pair 2 Classical genetics, quantitative genetics, hybrids Fishes, Poisonous - genetics Fundamental and applied biological sciences. Psychology Genetics of eukaryotes. Biological and molecular evolution Genome Humans Mice Microtubule-Associated Proteins - genetics Molecular Sequence Data Myosin Light Chains - genetics Rats Sequence Homology, Amino Acid Vertebrata |
| title | Regions of Human Chromosome 2 (2q32–q35) and Mouse Chromosome 1 Show Synteny with the Pufferfish Genome (Fugu rubripes) |
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