Behavioral and Metabolic Changes in Immature Rats during Seizures Induced by Homocysteic Acid: The Protective Effect of NMDA and Non-NMDA Receptor Antagonists

Bilateral intracerebroventricular infusion of dl-homocysteic acid (DL-HCA) (600 nmol on each side) to immature 12-day-old rats induced generalized clonic-tonic seizures, recurring frequently for at least 90 min, with a high rate of survival. Electrographic recordings from sensorimotor cortex, hippoc...

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Veröffentlicht in:	Experimental neurology 2000-01, Vol.161 (1), p.336-345
Hauptverfasser:	Folbergrová, Jaroslava, Haugvicová, Renata, Mareš, Pavel
Format:	Artikel
Sprache:	eng
Schlagworte:	2-Amino-5-phosphonovalerate - analogs & derivatives 2-Amino-5-phosphonovalerate - pharmacology [formula omitted]-homocysteic acid Age Factors Animals Cerebral Cortex - chemistry Cerebral Cortex - metabolism Cerebral Cortex - physiopathology Disease Models, Animal Dizocilpine Maleate - pharmacology EEG Electroencephalography Energy Metabolism - drug effects Energy Metabolism - physiology energy metabolites Epilepsy - chemically induced Epilepsy - drug therapy Epilepsy - metabolism Excitatory Amino Acid Antagonists - pharmacology Glucose - metabolism Homocysteine - analogs & derivatives immature rats Injections, Intraventricular Male Neuroprotective Agents - pharmacology protection Quinoxalines - pharmacology Rats Rats, Wistar Receptors, N-Methyl-D-Aspartate - physiology seizures Seizures - chemically induced Seizures - drug therapy Seizures - metabolism
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