Astrocyte Mitochondria: A Substrate for Iron Deposition in the Aging Rat Substantia Nigra

Little is currently known concerning the cellular substrates for, and the mechanisms mediating the pathological deposition of, redox-active brain iron in Parkinson's disease. In various subcortical brain regions, populations of astroglia progressively accumulate peroxidase-positive cytoplasmic...

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Veröffentlicht in:	Experimental neurology 1998-08, Vol.152 (2), p.188-196
Hauptverfasser:	Schipper, Hyman M., Vininsky, Rachelle, Brull, Richard, Small, Lorne, Brawer, James R.
Format:	Artikel
Sprache:	eng
Schlagworte:	aging Aging - metabolism Aging - pathology Animals astrocyte Astrocytes - metabolism Astrocytes - ultrastructure Biological and medical sciences Development. Senescence. Regeneration. Transplantation Disease Models, Animal Fundamental and applied biological sciences. Psychology Glial Fibrillary Acidic Protein - analysis Histocytochemistry iron Iron - metabolism Male Microscopy, Electron Mitochondria - metabolism Mitochondria - ultrastructure Oxidation-Reduction oxidative stress Parkinson Disease - metabolism Parkinson Disease - pathology Parkinson's disease Rats Rats, Sprague-Dawley substantia nigra Substantia Nigra - metabolism Substantia Nigra - ultrastructure Vertebrates: nervous system and sense organs
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