The Downregulation of GAP-43 Is Not Responsible for the Failure of Regeneration in Freeze-Killed Nerve Grafts in the Rat

Freeze-killed nerve grafts in rats are able to support limited axonal regeneration from severed peripheral nerves, but by 6 weeks postoperation, axonal elongation through the grafts ceases. To find out whether this limited regeneration may be related to GAP-43 expression, 4-cm freeze-killed nerve gr...

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Veröffentlicht in:	Experimental neurology 1994-10, Vol.129 (2), p.311-320
Hauptverfasser:	Chong, M.S., Woolf, C.J., Andrews, P., Turmaine, M., Schreyer, D.J., Anderson, P.N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Axons - metabolism Axons - physiology Axons - ultrastructure Biological and medical sciences Cranial nerves. Peripheral nerves. Autonomic nervous system Freeze Drying Ganglia, Spinal - metabolism Ganglia, Spinal - physiology GAP-43 Protein Gene Expression In Situ Hybridization Male Medical sciences Membrane Glycoproteins - analysis Membrane Glycoproteins - biosynthesis Microscopy, Electron Nerve Crush Nerve Regeneration Nerve Tissue Proteins - analysis Nerve Tissue Proteins - biosynthesis Neurofilament Proteins - biosynthesis Neurosurgery Peripheral Nerves - metabolism Peripheral Nerves - transplantation Rats Rats, Inbred F344 RNA, Messenger - analysis RNA, Messenger - biosynthesis Spinal Cord - metabolism Spinal Cord - physiology Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Tibial Nerve - metabolism Tibial Nerve - physiology Tibial Nerve - transplantation Time Factors
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