Adeno-Associated Virus Is Associated with a Lower Risk of High-Grade Cervical Neoplasia
Adeno-associated virus (AAV) is a ubiquitous human helper-dependent parvovirus which may interact with human papillomaviruses (HPV) to modify a woman's risk of cervical neoplasia. This analysis was nested in a cohort study of low-income women receiving Pap smears as part of their family plannin...
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| Veröffentlicht in: | Experimental and molecular pathology 2001-04, Vol.70 (2), p.83-89 |
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| container_title | Experimental and molecular pathology |
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| creator | Coker, Ann L. Russell, Rebecca B. Bond, Sharon M. Pirisi, Lucia Liu, Yong Mane, Michael Kokorina, Natalia Gerasimova, Tsilya Hermonat, Paul L. |
| description | Adeno-associated virus (AAV) is a ubiquitous human helper-dependent parvovirus which may interact with human papillomaviruses (HPV) to modify a woman's risk of cervical neoplasia. This analysis was nested in a cohort study of low-income women receiving Pap smears as part of their family planning services. We selected cases (55 with high-grade cervical squamous intraepithelial lesions (HSIL) and 162 with low-grade LSIL) and controls (96 women with normal cervical cytology) and analyzed cervical DNA for AAV, using PCR amplification/dot blot hybridization, and HPV, using hybrid capture I. AAV positivity was associated with a significantly reduced risk of HSIL (age and HPV-adjusted odds ratio (aOR) = 0.32) yet not with LSIL (aOR = 0.78); 53.8% of HSIL, 66.9% of LSIL, and 70.7% of controls were AAV+. AAV appears to interact with HPV to reduce SIL risk; relative to the HPV−/AAV+ exposure, the respective aORs for HSIL and HPV+/AAV−, HPV+/AAV+, and HPV−/AAV+ were 17.0, 6.9, and 3.5. AAV+ was not associated with age, race, HPV status, or sexual or reproductive risk factors. These results strongly suggest that AAV may play a protective or inhibitory role in late stage cervical carcinogenesis. This conclusion needs to be verified in additional epidemiologic studies. |
| doi_str_mv | 10.1006/exmp.2000.2347 |
| format | Article |
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This analysis was nested in a cohort study of low-income women receiving Pap smears as part of their family planning services. We selected cases (55 with high-grade cervical squamous intraepithelial lesions (HSIL) and 162 with low-grade LSIL) and controls (96 women with normal cervical cytology) and analyzed cervical DNA for AAV, using PCR amplification/dot blot hybridization, and HPV, using hybrid capture I. AAV positivity was associated with a significantly reduced risk of HSIL (age and HPV-adjusted odds ratio (aOR) = 0.32) yet not with LSIL (aOR = 0.78); 53.8% of HSIL, 66.9% of LSIL, and 70.7% of controls were AAV+. AAV appears to interact with HPV to reduce SIL risk; relative to the HPV−/AAV+ exposure, the respective aORs for HSIL and HPV+/AAV−, HPV+/AAV+, and HPV−/AAV+ were 17.0, 6.9, and 3.5. AAV+ was not associated with age, race, HPV status, or sexual or reproductive risk factors. These results strongly suggest that AAV may play a protective or inhibitory role in late stage cervical carcinogenesis. This conclusion needs to be verified in additional epidemiologic studies.</description><identifier>ISSN: 0014-4800</identifier><identifier>EISSN: 1096-0945</identifier><identifier>DOI: 10.1006/exmp.2000.2347</identifier><identifier>PMID: 11263951</identifier><identifier>CODEN: EXMPA6</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>adeno-associated virus ; Adult ; Ambulatory Care Facilities ; Biological and medical sciences ; Carcinoma, Squamous Cell - virology ; Case-Control Studies ; cervical neoplasms, papillomavirus, epidemiology ; Cohort Studies ; Dependovirus - genetics ; Dependovirus - isolation & purification ; DNA, Viral - analysis ; Female ; Female genital diseases ; Gynecology. Andrology. Obstetrics ; Humans ; Medical sciences ; Papanicolaou Test ; Papillomaviridae - isolation & purification ; Polymerase Chain Reaction ; Risk Factors ; sexually transmitted infection ; Socioeconomic Factors ; Tumors ; Uterine Cervical Neoplasms - virology ; Vaginal Smears ; women</subject><ispartof>Experimental and molecular pathology, 2001-04, Vol.70 (2), p.83-89</ispartof><rights>2001 Academic Press</rights><rights>2001 INIST-CNRS</rights><rights>Copyright 2001 Academic Press.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c368t-98fba9943362a0f19071ea1491a2f291b2aa39a28073339e83b8ba8571b2bfce3</citedby><cites>FETCH-LOGICAL-c368t-98fba9943362a0f19071ea1491a2f291b2aa39a28073339e83b8ba8571b2bfce3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0014480000923475$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=957656$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11263951$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Coker, Ann L.</creatorcontrib><creatorcontrib>Russell, Rebecca B.</creatorcontrib><creatorcontrib>Bond, Sharon M.</creatorcontrib><creatorcontrib>Pirisi, Lucia</creatorcontrib><creatorcontrib>Liu, Yong</creatorcontrib><creatorcontrib>Mane, Michael</creatorcontrib><creatorcontrib>Kokorina, Natalia</creatorcontrib><creatorcontrib>Gerasimova, Tsilya</creatorcontrib><creatorcontrib>Hermonat, Paul L.</creatorcontrib><title>Adeno-Associated Virus Is Associated with a Lower Risk of High-Grade Cervical Neoplasia</title><title>Experimental and molecular pathology</title><addtitle>Exp Mol Pathol</addtitle><description>Adeno-associated virus (AAV) is a ubiquitous human helper-dependent parvovirus which may interact with human papillomaviruses (HPV) to modify a woman's risk of cervical neoplasia. This analysis was nested in a cohort study of low-income women receiving Pap smears as part of their family planning services. We selected cases (55 with high-grade cervical squamous intraepithelial lesions (HSIL) and 162 with low-grade LSIL) and controls (96 women with normal cervical cytology) and analyzed cervical DNA for AAV, using PCR amplification/dot blot hybridization, and HPV, using hybrid capture I. AAV positivity was associated with a significantly reduced risk of HSIL (age and HPV-adjusted odds ratio (aOR) = 0.32) yet not with LSIL (aOR = 0.78); 53.8% of HSIL, 66.9% of LSIL, and 70.7% of controls were AAV+. AAV appears to interact with HPV to reduce SIL risk; relative to the HPV−/AAV+ exposure, the respective aORs for HSIL and HPV+/AAV−, HPV+/AAV+, and HPV−/AAV+ were 17.0, 6.9, and 3.5. AAV+ was not associated with age, race, HPV status, or sexual or reproductive risk factors. These results strongly suggest that AAV may play a protective or inhibitory role in late stage cervical carcinogenesis. This conclusion needs to be verified in additional epidemiologic studies.</description><subject>adeno-associated virus</subject><subject>Adult</subject><subject>Ambulatory Care Facilities</subject><subject>Biological and medical sciences</subject><subject>Carcinoma, Squamous Cell - virology</subject><subject>Case-Control Studies</subject><subject>cervical neoplasms, papillomavirus, epidemiology</subject><subject>Cohort Studies</subject><subject>Dependovirus - genetics</subject><subject>Dependovirus - isolation & purification</subject><subject>DNA, Viral - analysis</subject><subject>Female</subject><subject>Female genital diseases</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Papanicolaou Test</subject><subject>Papillomaviridae - isolation & purification</subject><subject>Polymerase Chain Reaction</subject><subject>Risk Factors</subject><subject>sexually transmitted infection</subject><subject>Socioeconomic Factors</subject><subject>Tumors</subject><subject>Uterine Cervical Neoplasms - virology</subject><subject>Vaginal Smears</subject><subject>women</subject><issn>0014-4800</issn><issn>1096-0945</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kMtLw0AQhxdRbK1ePcqC58TZ3bz2WIq2haIgPo5hspnY1bYJu33of29Ci3rxNDDzzTC_j7FLAaEASG7oc9mEEgBCqaL0iPUF6CQAHcXHrA8goiDKAHrszPv3ltIg5CnrCSETpWPRZ6_DklZ1MPS-NhbXVPIX6zaeTz3_09vZ9Zwjn9U7cvzR-g9eV3xi3-bB2GFJfERuaw0u-D3VzQK9xXN2UuHC08WhDtjz3e3TaBLMHsbT0XAWGJVk60BnVYFaR0olEqESGlJBKCItUFZSi0IiKo0yg1QppSlTRVZgFqftpKgMqQEL93eNq713VOWNs0t0X7mAvDOUd4byzlDeGWoXrvYLzaZYUvmLH5S0wPUBQN9GqhyujPU_nI7TJE5aKttT1IbbWnK5N5ZWhkrryKzzsrb_ffAN5--Afw</recordid><startdate>20010401</startdate><enddate>20010401</enddate><creator>Coker, Ann L.</creator><creator>Russell, Rebecca B.</creator><creator>Bond, Sharon M.</creator><creator>Pirisi, Lucia</creator><creator>Liu, Yong</creator><creator>Mane, Michael</creator><creator>Kokorina, Natalia</creator><creator>Gerasimova, Tsilya</creator><creator>Hermonat, Paul L.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20010401</creationdate><title>Adeno-Associated Virus Is Associated with a Lower Risk of High-Grade Cervical Neoplasia</title><author>Coker, Ann L. ; Russell, Rebecca B. ; Bond, Sharon M. ; Pirisi, Lucia ; Liu, Yong ; Mane, Michael ; Kokorina, Natalia ; Gerasimova, Tsilya ; Hermonat, Paul L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c368t-98fba9943362a0f19071ea1491a2f291b2aa39a28073339e83b8ba8571b2bfce3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>adeno-associated virus</topic><topic>Adult</topic><topic>Ambulatory Care Facilities</topic><topic>Biological and medical sciences</topic><topic>Carcinoma, Squamous Cell - virology</topic><topic>Case-Control Studies</topic><topic>cervical neoplasms, papillomavirus, epidemiology</topic><topic>Cohort Studies</topic><topic>Dependovirus - genetics</topic><topic>Dependovirus - isolation & purification</topic><topic>DNA, Viral - analysis</topic><topic>Female</topic><topic>Female genital diseases</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Papanicolaou Test</topic><topic>Papillomaviridae - isolation & purification</topic><topic>Polymerase Chain Reaction</topic><topic>Risk Factors</topic><topic>sexually transmitted infection</topic><topic>Socioeconomic Factors</topic><topic>Tumors</topic><topic>Uterine Cervical Neoplasms - virology</topic><topic>Vaginal Smears</topic><topic>women</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Coker, Ann L.</creatorcontrib><creatorcontrib>Russell, Rebecca B.</creatorcontrib><creatorcontrib>Bond, Sharon M.</creatorcontrib><creatorcontrib>Pirisi, Lucia</creatorcontrib><creatorcontrib>Liu, Yong</creatorcontrib><creatorcontrib>Mane, Michael</creatorcontrib><creatorcontrib>Kokorina, Natalia</creatorcontrib><creatorcontrib>Gerasimova, Tsilya</creatorcontrib><creatorcontrib>Hermonat, Paul L.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Experimental and molecular pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Coker, Ann L.</au><au>Russell, Rebecca B.</au><au>Bond, Sharon M.</au><au>Pirisi, Lucia</au><au>Liu, Yong</au><au>Mane, Michael</au><au>Kokorina, Natalia</au><au>Gerasimova, Tsilya</au><au>Hermonat, Paul L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Adeno-Associated Virus Is Associated with a Lower Risk of High-Grade Cervical Neoplasia</atitle><jtitle>Experimental and molecular pathology</jtitle><addtitle>Exp Mol Pathol</addtitle><date>2001-04-01</date><risdate>2001</risdate><volume>70</volume><issue>2</issue><spage>83</spage><epage>89</epage><pages>83-89</pages><issn>0014-4800</issn><eissn>1096-0945</eissn><coden>EXMPA6</coden><abstract>Adeno-associated virus (AAV) is a ubiquitous human helper-dependent parvovirus which may interact with human papillomaviruses (HPV) to modify a woman's risk of cervical neoplasia. This analysis was nested in a cohort study of low-income women receiving Pap smears as part of their family planning services. We selected cases (55 with high-grade cervical squamous intraepithelial lesions (HSIL) and 162 with low-grade LSIL) and controls (96 women with normal cervical cytology) and analyzed cervical DNA for AAV, using PCR amplification/dot blot hybridization, and HPV, using hybrid capture I. AAV positivity was associated with a significantly reduced risk of HSIL (age and HPV-adjusted odds ratio (aOR) = 0.32) yet not with LSIL (aOR = 0.78); 53.8% of HSIL, 66.9% of LSIL, and 70.7% of controls were AAV+. AAV appears to interact with HPV to reduce SIL risk; relative to the HPV−/AAV+ exposure, the respective aORs for HSIL and HPV+/AAV−, HPV+/AAV+, and HPV−/AAV+ were 17.0, 6.9, and 3.5. AAV+ was not associated with age, race, HPV status, or sexual or reproductive risk factors. These results strongly suggest that AAV may play a protective or inhibitory role in late stage cervical carcinogenesis. This conclusion needs to be verified in additional epidemiologic studies.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>11263951</pmid><doi>10.1006/exmp.2000.2347</doi><tpages>7</tpages></addata></record> |
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| ispartof | Experimental and molecular pathology, 2001-04, Vol.70 (2), p.83-89 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | adeno-associated virus Adult Ambulatory Care Facilities Biological and medical sciences Carcinoma, Squamous Cell - virology Case-Control Studies cervical neoplasms, papillomavirus, epidemiology Cohort Studies Dependovirus - genetics Dependovirus - isolation & purification DNA, Viral - analysis Female Female genital diseases Gynecology. Andrology. Obstetrics Humans Medical sciences Papanicolaou Test Papillomaviridae - isolation & purification Polymerase Chain Reaction Risk Factors sexually transmitted infection Socioeconomic Factors Tumors Uterine Cervical Neoplasms - virology Vaginal Smears women |
| title | Adeno-Associated Virus Is Associated with a Lower Risk of High-Grade Cervical Neoplasia |
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