Involvement of TNF α, IL-1β and IL-1 Receptor Antagonist in LPS-induced Rabbit Uveitis

The objective of the study was to investigate involvement of TNFα, IL-1β and IL-1 receptor antagonist (IL-1Ra) in lipopolysaccharide (LPS)-induced uveitis. Intravitreal injection of LPS (100 ng) to rabbits induced a massive leukocyte infiltration and protein leakage into the aqueous humor. Aqueous l...

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Veröffentlicht in:	Experimental eye research 1998-05, Vol.66 (5), p.547-557
Hauptverfasser:	MO, JUN-SONG, MATSUKAWA, AKIHIRO, OHKAWARA, SUSUMU, YOSHINAGA, MASARU
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Down-Regulation Enzyme-Linked Immunosorbent Assay Female IL-1 IL-1 receptor antagonist Immunohistochemistry Interleukin-1 - metabolism Interleukin-1 - toxicity Leukocytes - metabolism Lipopolysaccharides - toxicity LPS Lymphocyte Depletion Medical sciences Monocytes - metabolism Neutrophils - metabolism Ophthalmology Rabbits Receptors, Interleukin-1 - antagonists & inhibitors TNFα Tumor Necrosis Factor-alpha - metabolism Tumor Necrosis Factor-alpha - toxicity Uvea diseases uveitis Uveitis - chemically induced Uveitis - metabolism
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