Induction of Human Thioredoxin in Cultured Human Retinal Pigment Epithelial Cells through Cyclic AMP-dependent Pathway; Involvement in the Cytoprotective Activity of Prostaglandin E1

Human thioredoxin is one of the oxidative stress-inducible proteins and has a protective function against oxidant-induced injury. To evaluate the possible involvement of thioredoxin in the cytoprotective function of prostaglandin E1, we analysed the effect of prostaglandin E1on cellular injury by hy...

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Veröffentlicht in:	Experimental eye research 1997-11, Vol.65 (5), p.645-652
Hauptverfasser:	YAMAMOTO, MIHO, SATO, NORIHITO, TAJIMA, HISAO, FURUKE, KEIZO, OHIRA, AKIHIRO, HONDA, YOSHIHITO, YODOI, JUNJI
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenylyl Cyclases - metabolism Adult Alprostadil - metabolism Biological and medical sciences Bucladesine - pharmacology Cell Survival - drug effects Cells, Cultured Colforsin - pharmacology Cryoprotective Agents cyclic AMP Cyclic AMP - analogs & derivatives Cyclic AMP - metabolism Cyclic AMP - pharmacology Cyclic AMP-Dependent Protein Kinases - analysis cytoprotection Enzyme Inhibitors - pharmacology Epoprostenol - pharmacology Eye and associated structures. Visual pathways and centers. Vision Fundamental and applied biological sciences. Psychology human thioredoxin Humans hydrogen peroxide Hydrogen Peroxide - pharmacology Oxidants - pharmacology Oxidative Stress Pigment Epithelium of Eye - metabolism prostaglandin E1 retinal pigment epithelial cells Signal Transduction - drug effects Thionucleotides - pharmacology Thioredoxins - metabolism Vertebrates: nervous system and sense organs
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