Effects of Thalidomide and Related Metabolites in a Mouse Corneal Model of Neovascularization

Thalidomide, when administered orally, is an inhibitor of angiogenesis in the basic fibroblast growth factor (bFGF)-induced rabbit cornea micropocket assay. We now show in the mouse that thalidomide given intraperitoneally but not orally significantly inhibits bFGF-induced and vascular endothelial g...

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Veröffentlicht in:	Experimental eye research 1997-06, Vol.64 (6), p.971-978
Hauptverfasser:	KENYON, BÄRBEL M., BROWNE, FIONA, D'AMATO, ROBERT J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral angiogenesis Animals Biological and medical sciences cornea Cornea - blood supply Corneal Neovascularization - etiology Corneal Neovascularization - prevention & control Drug toxicity and drugs side effects treatment Endothelial Growth Factors Female Fibroblast Growth Factor 2 Glutamates - therapeutic use growth factor Injections, Intraperitoneal Lymphokines Medical sciences Mice Mice, Inbred C57BL neovascularization Pharmacology. Drug treatments Structure-Activity Relationship Teratogens - chemistry Teratogens - pharmacology thalidomide Thalidomide - analogs & derivatives Thalidomide - chemistry Thalidomide - pharmacology Thalidomide - therapeutic use Toxicity: eye tumor necrosis factor-alpha Tumor Necrosis Factor-alpha - antagonists & inhibitors Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factors
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