Hyperbaric Oxygen Inhibits the Growth of Cultured Rabbit Lens Epithelial Cells Without Affecting Glutathione Level

Studies on human patients and experimental animals indicate that hyperbaric O 2 can opacity the lens nucleus and damage the lens epithelium in vivo. Here we investigate the effects of hyperbaric O 2 on cultured rabbit lens epithelial cells (LECs). When the cells were exposed to 50 atm O 2 (99% O 2 +...

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Veröffentlicht in:	Experimental eye research 1993-04, Vol.56 (4), p.443-452
Hauptverfasser:	Padgaonkar, Vanita, Giblin, Frank J., Reddan, John R., Dziedzic, Dorothy C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cell Survival - drug effects Cells, Cultured DNA - biosynthesis DNA Damage DNA repair enzyme DNA strand breaks DNA synthesis Dose-Response Relationship, Drug Epithelial Cells Eye and associated structures. Visual pathways and centers. Vision Fundamental and applied biological sciences. Psychology Glutathione - metabolism glutathione, glycolysis hyperbaric oxygen Hyperbaric Oxygenation lens epithelial cells Lens, Crystalline - cytology Lens, Crystalline - drug effects Lens, Crystalline - metabolism Methionine - metabolism mitosis Mitosis - drug effects oxidative damage Oxygen - toxicity Poly(ADP-ribose) Polymerases - metabolism protein synthesis rabbit Rabbits Time Factors Vertebrates: nervous system and sense organs
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