Activation of a Cysteine Protease in MCF-7 and T47D Breast Cancer Cells during β-Lapachone-Mediated Apoptosis

β-Lapachone (β-lap) effectively killed MCF-7 and T47D cell lines via apoptosis in a cell-cycle-independent manner. However, the mechanism by which this compound activated downstream proteolytic execution processes were studied. At low concentrations, β-lap activated the caspase-mediated pathway, sim...

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Veröffentlicht in:	Experimental cell research 2000-03, Vol.255 (2), p.144-155
Hauptverfasser:	Pink, John J., Wuerzberger-Davis, Shelly, Tagliarino, Colleen, Planchon, Sarah M., Yang, XiaoHe, Froelich, Christopher J., Boothman, David A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics, Antineoplastic - pharmacology apoptosis Apoptosis - drug effects breast cancer Breast Neoplasms - enzymology Breast Neoplasms - pathology calpain caspase Cysteine Endopeptidases - metabolism Enzyme Activation - drug effects Female Humans Naphthoquinones - pharmacology PARP poly(ADP)-ribose polymerase topotecan Tumor Cells, Cultured β-lapachone
Online-Zugang:	Volltext
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