Regulation of Motility and Protease Expression in PKC-Mediated Induction of MCF-7 Breast Cancer Cell Invasiveness

We investigated a potentially central role of protein kinase C (PKC) in controlling multiple pathways in breast cancer cell invasiveness. To do this we evaluated the ability of pharmacologic agents that alter PKC activity to regulate the behavior of the poorly invasive human breast cancer cell line...

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Veröffentlicht in:	Experimental cell research 1999-02, Vol.247 (1), p.105-113
Hauptverfasser:	Johnson, M.D., Torri, J.A., Lippman, M.E., Dickson, R.B.
Format:	Artikel
Sprache:	eng
Schlagworte:	breast cancer Breast Neoplasms - enzymology Breast Neoplasms - pathology Bryostatins Cathepsin D - biosynthesis Cell Movement Endopeptidases - biosynthesis Enzyme Activation - drug effects Humans invasion Lactones - pharmacology Macrolides Metalloendopeptidases - biosynthesis motility Neoplasm Invasiveness protein kinase C Protein Kinase C - physiology proteinase Receptors, Cell Surface - biosynthesis Receptors, Urokinase Plasminogen Activator Tetradecanoylphorbol Acetate - pharmacology Tumor Cells, Cultured Urokinase-Type Plasminogen Activator - biosynthesis Urokinase-Type Plasminogen Activator - metabolism
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