The Effect of a 10-Day Space Flight on the Function, Phenotype, and Adhesion Molecule Expression of Splenocytes and Lymph Node Lymphocytes

Previous studies have indicated that space flight affects the activation of lymphocytes from humans, monkeys, and rodents. In rats, where lymphocytes from blood, spleen, and lymph nodes have been tested, the accumulated data suggest that the effects of flight on various cells are lymphoid organ-spec...

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Veröffentlicht in:	Experimental cell research 1995-07, Vol.219 (1), p.102-109
Hauptverfasser:	Grove, Deborah S., Pishak, Sharon A., Mastro, Andrea M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Animals Antigens, CD - metabolism B-Lymphocytes - immunology CD2 Antigens - metabolism CD4 Antigens - metabolism CD5 Antigens CD8 Antigens - metabolism Cell Adhesion Molecules - biosynthesis Concanavalin A - pharmacology Interleukin-2 - biosynthesis Ionomycin - pharmacology Lymph Nodes - immunology Lymphocyte Activation Lymphocytes - drug effects Lymphocytes - immunology Male Organ Size Phenotype Phytohemagglutinins - pharmacology Rats Rats, Inbred F344 Space Flight Spleen - anatomy & histology Spleen - cytology Spleen - immunology T-Lymphocytes - immunology Tetradecanoylphorbol Acetate - pharmacology
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Beschreibung
Zusammenfassung:	Previous studies have indicated that space flight affects the activation of lymphocytes from humans, monkeys, and rodents. In rats, where lymphocytes from blood, spleen, and lymph nodes have been tested, the accumulated data suggest that the effects of flight on various cells are lymphoid organ-specific. Thus, cells may be affected by variations in trafficking brought about by fluid shifts in microgravity (
ISSN:	0014-4827 1090-2422
DOI:	10.1006/excr.1995.1210