SEK1/MKK4-Mediated SAPK/JNK Signaling Participates in Embryonic Hepatoblast Proliferation via a Pathway Different from NF-κB-Induced Anti-Apoptosis

Mice lacking the stress-signaling kinase SEK1 die from embryonic day 10.5 (E10.5) to E12.5. Although a defect in liver formation is accompanied with the embryonic lethality of sek1 −/− mice, the mechanism of the liver defect has remained unknown. In the present study, we first produced a monoclonal...

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Veröffentlicht in:	Developmental biology 2002-10, Vol.250 (2), p.332-347
Hauptverfasser:	Watanabe, Tomomi, Nakagawa, Kentaro, Ohata, Shinya, Kitagawa, Daiju, Nishitai, Gen, Seo, Jungwon, Tanemura, Shuhei, Shimizu, Nao, Kishimoto, Hiroyuki, Wada, Teiji, Aoki, Junken, Arai, Hiroyuki, Iwatsubo, Takeshi, Mochita, Miyuki, Watanabe, Toshio, Satake, Masanobu, Ito, Yoshiaki, Matsuyama, Toshifumi, Mak, Tak W., Penninger, Josef M., Nishina, Hiroshi, Katada, Toshiaki
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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