IGF-I Synergizes with FGF-2 to Stimulate Oligodendrocyte Progenitor Entry into the Cell Cycle

Secreted peptide growth factors are critical extracellular signals that interact to promote the proliferation, differentiation, and survival of progenitor cells in developing tissues. IGF-I signaling through the IGF type I receptor provides a mitogenic signal for numerous cell types, including stem...

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Veröffentlicht in:	Developmental biology 2001-04, Vol.232 (2), p.414-423
Hauptverfasser:	Jiang, Fengjun, Frederick, Terra J., Wood, Teresa L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bromodeoxyuridine - metabolism cell cycle Cell Cycle - drug effects Cells, Cultured DNA - biosynthesis Drug Synergism FGF-2 Fibroblast Growth Factor 2 - administration & dosage IGF-I Insulin-Like Growth Factor I - administration & dosage Kinetics O-2A progenitor oligodendrocyte Oligodendroglia - cytology Oligodendroglia - drug effects Oligodendroglia - metabolism PDGF Platelet-Derived Growth Factor - administration & dosage progression factor Rats S Phase - drug effects Stem Cells - cytology Stem Cells - drug effects Stem Cells - metabolism
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