Protein Kinase C-Related Kinase 2 Phosphorylates the Protein Synthesis Initiation Factor eIF4E in Starfish Oocytes

Phosphorylation of eIF4E is required for protein synthesis during starfish oocyte maturation. The activity of protein kinase C-related kinase 2 (PRK2) increases prior to the phosphorylation of eIF4E (G. Stapleton et al., 1998, Dev. Biol. 193, 34–46). We investigate here whether eIF4E is activated by...

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Veröffentlicht in:	Developmental biology 2000-12, Vol.228 (2), p.166-180
Hauptverfasser:	Lee, Shyh-Jye, Stapleton, Genevieve, Greene, Julia H., Hille, Merrill B.
Format:	Artikel
Sprache:	eng
Schlagworte:	4EBP Alanine Amino Acid Sequence Amino Acid Substitution Animals Biomarkers, Tumor - metabolism cAMP eIF4E Eukaryotic Initiation Factor-4E Female forskolin Humans Kinetics LY294002 Molecular Sequence Data Mutagenesis, Site-Directed oocyte maturation Oocytes - physiology Peptide Initiation Factors - chemistry Peptide Initiation Factors - genetics Peptide Initiation Factors - metabolism Peptide Mapping Phosphopeptides - chemistry Phosphorylation PI3 kinase PRK2 Protein Kinase C - metabolism rapamycin Recombinant Proteins - chemistry Recombinant Proteins - metabolism Sequence Alignment Sequence Homology, Amino Acid Serine Starfish
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