Dynamic Patterns of Retinoic Acid Synthesis and Response in the Developing Mammalian Heart

Retinoic acid (RA) has been implicated in cardiac morphogenesis by its teratogenic effects on the heart, although its role in normal cardiogenesis remains unknown. To define the parameters of RA action in cardiac morphogenesis, we analyzed the patterns of ligand synthesis, response, and inactivation...

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Veröffentlicht in:	Developmental biology 1998-07, Vol.199 (1), p.55-71
Hauptverfasser:	Moss, Jennifer B., Xavier-Neto, José, Shapiro, Michael D., Nayeem, Sara M., McCaffery, Peter, Dräger, Ursula C., Rosenthal, Nadia
Format:	Artikel
Sprache:	eng
Schlagworte:	Aldehyde Oxidoreductases - biosynthesis Animals Aorta, Thoracic - embryology beta-Galactosidase - biosynthesis Cytochrome P-450 Enzyme System - biosynthesis Endocardium - embryology Gene Expression Regulation, Developmental Gene Expression Regulation, Enzymologic Heart - drug effects Heart - embryology In Vitro Techniques Isoenzymes - biosynthesis Lac Operon Mice Mice, Transgenic Morphogenesis Oxygenases - biosynthesis Recombinant Proteins - biosynthesis Regulatory Sequences, Nucleic Acid Retinal Dehydrogenase Retinoic Acid 4-Hydroxylase Teratogens - metabolism Teratogens - pharmacology Tissue Distribution Tretinoin - metabolism Tretinoin - pharmacology
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