Induction of Rapid IL-β mRNA Degradation in THP-1 Cells Mediated Through the AU-Rich Region in the 3′UTR by a Radicicol Analogue

A radicicol analogue (analogue A) was found to inhibit interleukin 1 beta (IL-1β) and tumour necrosis factor alpha (tnf-α) secretion from THP-1 cells. If added to cells activated by interferon gamma and lipopolysaccharide, radicicol analogue A not only inhibited the secretion of IL-1β but also induc...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Cytokine (Philadelphia, Pa.) Pa.), 1996-10, Vol.8 (10), p.751-761
Hauptverfasser:	Kastelic, Tania, Schnyder, Jög, Leutwiler, Albert, Traber, René, Streit, Bruno, Niggli, Heinz, MacKenzie, Andrew, Cheneval, Dominique
Format:	Artikel
Sprache:	eng
Schlagworte:	3′UTR AUUUA motif mRNA degradation radicicol THP-1
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!