PREVENTIVE EFFECT OF HEPATOCYTE GROWTH FACTOR ON ACUTE SIDE EFFECTS OF CYCLOSPORIN A IN MICE

Cyclosporin A (CsA) is a potent, widely-prescribed immunosuppressant which has serious side effects. When recombinant human hepatocyte growth factor (rh-HGF) was co-administrated with CsA to mice, the severe digestive and/or neurological symptoms and degenerative changes in renal tubular cells and h...

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Veröffentlicht in:	Cytokine (Philadelphia, Pa.) Pa.), 1996-05, Vol.8 (5), p.387-394
Hauptverfasser:	Amaike, Hisashi, Matsumoto, Kunio, Oka, Takahiro, Nakamura, Toshikazu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Death - drug effects cyclosporin A Cyclosporine - administration & dosage Cyclosporine - toxicity Drug Antagonism hepatocyte growth factor Hepatocyte Growth Factor - administration & dosage Humans Interleukin-2 - biosynthesis Kidney - metabolism Kidney - pathology Liver - metabolism Liver - pathology Male Mice organotrophic factor Recombinant Proteins - administration & dosage RNA, Messenger - biosynthesis RNA, Messenger - drug effects
Online-Zugang:	Volltext
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