Synergistic Effects of IL-6 and IFN-γ on Carcinoembryonic Antigen (CEA) and HLA Expression by Human Colorectal Carcinoma Cells: Role for Endogenous IFN-β

When administered as single agents, both interferon gamma (IFN-γ) and interleukin 6 (IL-6) significantly increase carcinoembryonic antigen (CEA) and HLA class I antigen expression on the surface of human colorectal tumour cells. Studies were carried out to determine whether by combining those cytoki...

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Veröffentlicht in:	Cytokine (Philadelphia, Pa.) Pa.), 1995-02, Vol.7 (2), p.118-129
Hauptverfasser:	Dansky-Ullmann, Claudio, Salgaller, Michael, Adams, Sharon, Schlom, Jeffrey, Greiner, John W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Monoclonal - pharmacology Carcinoembryonic Antigen - biosynthesis Cell Line Colonic Neoplasms Colorectal Neoplasms Drug Synergism Flow Cytometry Gene Expression - drug effects Gene Expression Regulation, Neoplastic - drug effects Histocompatibility Antigens Class I - biosynthesis HLA-D Antigens - biosynthesis Humans Interferon-gamma - pharmacology Interferon-γ/interleukin 6/carcinoembryonic antigen/colon cancer Interleukin-6 - pharmacology Polymerase Chain Reaction - methods Recombinant Proteins RNA, Messenger - analysis RNA, Messenger - biosynthesis Tumor Cells, Cultured
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