Vitamin D3 and Its Synthetic Analogs Inhibit the Spontaneous in Vitro Immunoglobulin Production by SLE-Derived PBMC

The production of high-affinity pathogenic autoantibodies in systemic lupus erythematosus (SLE) may result from aberrant immune regulation. Since 1,25 dihydroxy vitamin D3 (1,25 D3) has immunoregulatory activity, we examined effects of 1,25 D3 and its analogs HM, V, MC1288, and KH1060 on autoantibod...

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Veröffentlicht in:	Clinical immunology (Orlando, Fla.) Fla.), 2001-04, Vol.99 (1), p.82-93
Hauptverfasser:	Linker-Israeli, M., Elstner, E., Klinenberg, J.R., Wallace, D.J., Koeffler, H.P.
Format:	Artikel
Sprache:	eng
Schlagworte:	1,25 D3 synthetic analogs autoimmunity Biological and medical sciences Immunomodulators lymphocytes Medical sciences Pharmacology. Drug treatments SLE vitamin D3
Online-Zugang:	Volltext
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