Impaired Induction ofc-fos/c-junGenes and of Transcriptional Regulatory Proteins Binding Distinctc-fos/c-junPromoter Elements in Activated Human T Cells during Aging

The activation of transcriptional factor c-Fos/c-Jun AP-1 is essential for normal T cell responsiveness and is often impaired in T cells during aging. In the present study, we investigated whether aberrancies in the regulation ofc-fos/c-junat the mRNA or protein level might underlie the age-associat...

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Veröffentlicht in:	Cellular immunology 1997-01, Vol.175 (1), p.41-50
Hauptverfasser:	Whisler, Ronald L., Chen, Ming, Beiqing, Liu, Carle, Kristen W.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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