C/EBPα AND C/EBPβ ARE PERSISTENTLY ASSOCIATED WITH THE RAT LIVER NUCLEAR MATRIX THROUGHOUT DEVELOPMENT AND THE ACUTE PHASE RESPONSE

C/EBPα AND C/EBPβ ARE PERSISTENTLY ASSOCIATED WITH THE RAT LIVER NUCLEAR MATRIX THROUGHOUT DEVELOPMENT AND THE ACUTE PHASE RESPONSE

The partitioning of C/EBPα and C/EBPβ on the nuclear matrix structure was examined during the different transcriptional activities accompanying liver development and the acute phase (AP) response. The presence of C/EBPα and C/EBPβ was established on the nuclear matrix. Their relative concentrations...

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Veröffentlicht in:Cell biology international 2000-10, Vol.24 (10), p.691-698
Hauptverfasser: Dinic, Svetlana, Ivanovic-Matic, Svetlana, Bogojevic, Desanka, Mihailovic, Mirjana, Poznanovic, Goran
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acute phase (AP) response
CCAAT/enhancer-binding proteins (C/EBP) α and β
nuclear matrix
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container_issue 10
container_start_page 691
container_title Cell biology international
container_volume 24
creator Dinic, Svetlana
Ivanovic-Matic, Svetlana
Bogojevic, Desanka
Mihailovic, Mirjana
Poznanovic, Goran
description The partitioning of C/EBPα and C/EBPβ on the nuclear matrix structure was examined during the different transcriptional activities accompanying liver development and the acute phase (AP) response. The presence of C/EBPα and C/EBPβ was established on the nuclear matrix. Their relative concentrations on the matrix always reflected the developmental stage- and AP-related fluctuations observed in the nuclear extract. Thus, they progressively increased as development proceeded, whereas during the AP response, C/EBPα decreased and C/EBPβ increased. In addition, the levels of both transcription factors were always notably higher in the nuclear matrix than in the extracts. We conclude that the observed changes and overall enrichment of the nuclear matrix with regulatory proteins is a reflection of the importance of such interactions for the in vivo functioning of C/EBP proteins.
doi_str_mv 10.1006/cbir.2000.0531
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subjects acute phase (AP) response
CCAAT/enhancer-binding proteins (C/EBP) α and β
nuclear matrix
title C/EBPα AND C/EBPβ ARE PERSISTENTLY ASSOCIATED WITH THE RAT LIVER NUCLEAR MATRIX THROUGHOUT DEVELOPMENT AND THE ACUTE PHASE RESPONSE
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