Synthesis and Properties of Two New Membrane-Impermeant High-Molecular-Weight Carbonic Anhydrase Inhibitors

The synthesis and inhibitory properties and stability of two nontoxic high-molecular-weight carbonic anhydrase inhibitors (F 3500 and POBUMS) are reported. F 3500 was prepared by the covalent linkage of aminobenzolamide, a potent carbonic anhydrase (CA) inhibitor, to polyoxyethylene bisacetic acid (...

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Veröffentlicht in:	Bioorganic chemistry 1996-09, Vol.24 (3), p.262-272
Hauptverfasser:	Conroy, Curtis W., Wynns, George C., Maren, Thomas H.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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