Arsenic Trioxide-Induced Apoptosis and Its Enhancement by Buthionine Sulfoximine in Hepatocellular Carcinoma Cell Lines

We treated four hepatocellular carcinoma cell lines, HLE, HLF, HuH7, and HepG2 with ATO and demonstrated that arsenic trioxide (ATO) at low doses (1–3 μM) induced a concentration-dependent suppression of cell growth in HLE, HLF, and HuH7. HLE cells underwent apoptosis at 2 μM ATO, which was executed...

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Veröffentlicht in:	Biochemical and biophysical research communications 2002, Vol.291 (4), p.861-867
Hauptverfasser:	Kito, Mariko, Akao, Yukihiro, Ohishi, Nobuko, Yagi, Kunio, Nozawa, Yoshinori
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - pharmacology Apoptosis arsenic trioxide Arsenicals - pharmacology buthionine sulfoximine Buthionine Sulfoximine - pharmacology Carcinoma, Hepatocellular - metabolism Carcinoma, Hepatocellular - pathology Carcinoma, Hepatocellular - ultrastructure Caspases - metabolism Cell Division - drug effects Cell Nucleus - ultrastructure DNA Fragmentation DNA, Neoplasm - analysis Dose-Response Relationship, Drug Drug Synergism Glutathione - metabolism hepatocellular carcinoma Humans Kinetics Liver Neoplasms - metabolism Liver Neoplasms - pathology Liver Neoplasms - ultrastructure oxidative stress Oxides - pharmacology Reactive Oxygen Species - metabolism Tumor Cells, Cultured
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