ERK Mediates Effects of Glycated Albumin in Mesangial Cells

The alterations in glomerular cell biology induced by glycated albumin resemble those caused by high ambient glucose, but are operative in physiologic (5.5 mM) glucose concentration. Recently, high glucose has been shown to activate extracellular signal-related kinase (ERK) in mesangial cells, but w...

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Veröffentlicht in:	Biochemical and biophysical research communications 2001-05, Vol.283 (3), p.641-643
Hauptverfasser:	Cohen, Margo P., Shea, Elizabeth, Shearman, Clyde W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Division - drug effects Cells, Cultured Enzyme Activation Enzyme Inhibitors - pharmacology Extracellular Matrix - drug effects Extracellular Matrix - metabolism Fibronectins - metabolism Flavonoids - pharmacology Glomerular Mesangium - cytology Glomerular Mesangium - drug effects Glomerular Mesangium - metabolism Mice Mitogen-Activated Protein Kinases - antagonists & inhibitors Mitogen-Activated Protein Kinases - metabolism Serum Albumin - metabolism Serum Albumin - pharmacology Signal Transduction
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