Homology Modeling of Nematode Caenorhabditis elegans CED3 Protein–Inhibitor Complex

CED3 protein, the product of a gene necessary for programmed cell death in the nematode Caenorhabditis elegans, is related to a highly specific cysteine protease family i.e., caspases. A tertiary-structural model has been constructed of a complex of the CED3 protein with tetrapeptide-aldehyde inhibi...

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Veröffentlicht in:	Biochemical and biophysical research communications 2001-02, Vol.281 (1), p.115-121
Hauptverfasser:	Azim, M.Kamran, Grossmann, J.Günter, Zaidi, Zafar H
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals apoptosis Aspartic Acid - chemistry Binding Sites Caenorhabditis elegans Caenorhabditis elegans Proteins caspase Caspase 3 Caspases - chemistry Caspases - metabolism CED3 protein Computer Simulation Cysteine Endopeptidases - chemistry Cysteine Endopeptidases - metabolism homology modeling Models, Molecular Molecular Sequence Data Mutagenesis, Site-Directed Oligopeptides - pharmacology programmed cell death Protein Binding Protein Conformation Protein Structure, Tertiary Sequence Homology, Amino Acid structure prediction Substrate Specificity
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