Possible Role of Calpain in Normal Processing of β-Amyloid Precursor Protein in Human Platelets

Abnormal proteolytic processing of β-amyloid precursor protein (APP) underlies the formation of amyloid plaques in aging and Alzheimer's disease. The proteases involved in the process have not been identified. Here we found that spontaneous proteolysis of intact APP in detergent-lysed human pla...

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Veröffentlicht in:	Biochemical and biophysical research communications 2000-06, Vol.273 (1), p.170-175
Hauptverfasser:	Chen, Ming, Durr, Jacques, Fernandez, Hugo L.
Format:	Artikel
Sprache:	eng
Schlagworte:	aging Alzheimer amyloid Amyloid beta-Peptides - chemistry Amyloid beta-Peptides - metabolism Amyloid beta-Protein Precursor - chemistry Amyloid beta-Protein Precursor - metabolism Amyloid beta-Protein Precursor - secretion Blood Platelets - cytology Blood Platelets - drug effects Blood Platelets - enzymology Blood Platelets - metabolism Calcimycin - pharmacology calcium Calcium - antagonists & inhibitors Calcium - pharmacology Calcium-Binding Proteins - pharmacology calpain Calpain - antagonists & inhibitors Calpain - metabolism Cations, Divalent - antagonists & inhibitors Cations, Divalent - pharmacology Cell Extracts Edetic Acid - pharmacology Egtazic Acid - pharmacology Endopeptidase K - metabolism Humans Hydrogen-Ion Concentration Inhibitory Concentration 50 Molecular Weight Peptide Fragments - pharmacology Protease Inhibitors - pharmacology Protein Processing, Post-Translational - drug effects Trypsin - metabolism
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