TSH and cAMP Do Not Signal Mitogenesis through Ras Activation

Ras activation by receptor tyrosine kinases or serpentine receptors is generally considered to be essential for G1 phase progression and mitogenesis. In the physiologically relevant model of primary dog thyrocytes, the accumulation of the GTP-bound form of Ras constituted an early convergence point...

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Veröffentlicht in:	Biochemical and biophysical research communications 2000-06, Vol.273 (1), p.154-158
Hauptverfasser:	Van Keymeulen, Alexandra, Roger, Pierre P., Dumont, Jacques E., Dremier, Sarah
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenylyl Cyclases - metabolism Animals cAMP Carbachol - pharmacology Cell Cycle - drug effects Cell Differentiation - drug effects Cells, Cultured Colforsin - pharmacology Cyclic AMP - metabolism Cyclic AMP - pharmacology Dogs Enzyme Activation - drug effects Epidermal Growth Factor - pharmacology Guanosine Triphosphate - metabolism Hepatocyte Growth Factor - pharmacology Insulin - pharmacology Mitogens - pharmacology phorbol esters proliferation Ras ras Proteins - metabolism Tetradecanoylphorbol Acetate - pharmacology thyroid Thyroid Gland - cytology Thyroid Gland - drug effects Thyroid Gland - enzymology Thyroid Gland - metabolism Thyrotropin - pharmacology Time Factors
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