Sck Interacts with KDR and Flt-1 via Its SH2 Domain

Vascular endothelial growth factor (VEGF) is one of the major angiogenesis regulators. It binds to its tyrosine kinase receptors, KDR and Flt-1. However, little is known about their downstream signal transduction properties. We screened human brain cDNA library using the yeast two-hybrid system with...

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Veröffentlicht in:	Biochemical and biophysical research communications 1998-10, Vol.251 (1), p.77-82
Hauptverfasser:	Igarashi, Katsuhide, Shigeta, Keiko, Isohara, Toshio, Yamano, Tomoka, Uno, Isao
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing Brain Chemistry Cell Line Cloning, Molecular Endothelium, Vascular - metabolism Humans Mutagenesis, Site-Directed Phosphotyrosine - metabolism Protein Binding - genetics Proteins - genetics Proteins - metabolism Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism Receptor Protein-Tyrosine Kinases - genetics Receptor Protein-Tyrosine Kinases - metabolism Receptors, Growth Factor - genetics Receptors, Growth Factor - metabolism Receptors, Vascular Endothelial Growth Factor Shc Signaling Adaptor Proteins Src Homology 2 Domain-Containing, Transforming Protein 2 src Homology Domains Vascular Endothelial Growth Factor Receptor-1
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