Lycopene in Association with α-Tocopherol Inhibits at Physiological Concentrations Proliferation of Prostate Carcinoma Cells
The effect of lycopene alone or in association with other antioxidants was studied on the growth of two different human prostate carcinoma cell lines (the androgen insensitive DU-145 and PC-3). It was found that lycopene alone was not a potent inhibitor of prostate carcinoma cell proliferation. Howe...
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| Veröffentlicht in: | Biochemical and biophysical research communications 1998-09, Vol.250 (3), p.582-585 |
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| container_title | Biochemical and biophysical research communications |
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| creator | Pastori, Mariella Pfander, Hanspeter Boscoboinik, Daniel Azzi, Angelo |
| description | The effect of lycopene alone or in association with other antioxidants was studied on the growth of two different human prostate carcinoma cell lines (the androgen insensitive DU-145 and PC-3). It was found that lycopene alone was not a potent inhibitor of prostate carcinoma cell proliferation. However, the simultaneous addition of lycopene together with α-tocopherol, at physiological concentrations (less than 1 μM and 50 μM, respectively), resulted in a strong inhibitory effect of prostate carcinoma cell proliferation, which reached values close to 90 %. The effect of lycopene with α-tocopherol was synergistic and was not shared by β-tocopherol, ascorbic acid and probucol. |
| doi_str_mv | 10.1006/bbrc.1998.9351 |
| format | Article |
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The effect of lycopene with α-tocopherol was synergistic and was not shared by β-tocopherol, ascorbic acid and probucol.</description><identifier>ISSN: 0006-291X</identifier><identifier>EISSN: 1090-2104</identifier><identifier>DOI: 10.1006/bbrc.1998.9351</identifier><identifier>PMID: 9784387</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Antioxidants - pharmacology ; CARCINOMA ; Carcinoma - pathology ; CARCINOME ; Carotenoids - pharmacology ; Cell Division - drug effects ; CELLS ; CELLULE ; CELULAS ; Drug Synergism ; Humans ; LICOPENO ; LYCOPENE ; Male ; Prostatic Neoplasms - pathology ; TOCOFEROLES ; TOCOPHEROL ; TOCOPHEROLS ; Tumor Cells, Cultured ; Vitamin E - pharmacology</subject><ispartof>Biochemical and biophysical research communications, 1998-09, Vol.250 (3), p.582-585</ispartof><rights>1998 Academic Press</rights><rights>Copyright 1998 Academic Press.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c361t-b657a188b54618a78a49894763ae758a051e410ba7e41cfd98d8a9c4413dd5563</citedby><cites>FETCH-LOGICAL-c361t-b657a188b54618a78a49894763ae758a051e410ba7e41cfd98d8a9c4413dd5563</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1006/bbrc.1998.9351$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,782,786,3552,27931,27932,46002</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9784387$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pastori, Mariella</creatorcontrib><creatorcontrib>Pfander, Hanspeter</creatorcontrib><creatorcontrib>Boscoboinik, Daniel</creatorcontrib><creatorcontrib>Azzi, Angelo</creatorcontrib><title>Lycopene in Association with α-Tocopherol Inhibits at Physiological Concentrations Proliferation of Prostate Carcinoma Cells</title><title>Biochemical and biophysical research communications</title><addtitle>Biochem Biophys Res Commun</addtitle><description>The effect of lycopene alone or in association with other antioxidants was studied on the growth of two different human prostate carcinoma cell lines (the androgen insensitive DU-145 and PC-3). It was found that lycopene alone was not a potent inhibitor of prostate carcinoma cell proliferation. However, the simultaneous addition of lycopene together with α-tocopherol, at physiological concentrations (less than 1 μM and 50 μM, respectively), resulted in a strong inhibitory effect of prostate carcinoma cell proliferation, which reached values close to 90 %. The effect of lycopene with α-tocopherol was synergistic and was not shared by β-tocopherol, ascorbic acid and probucol.</description><subject>Antioxidants - pharmacology</subject><subject>CARCINOMA</subject><subject>Carcinoma - pathology</subject><subject>CARCINOME</subject><subject>Carotenoids - pharmacology</subject><subject>Cell Division - drug effects</subject><subject>CELLS</subject><subject>CELLULE</subject><subject>CELULAS</subject><subject>Drug Synergism</subject><subject>Humans</subject><subject>LICOPENO</subject><subject>LYCOPENE</subject><subject>Male</subject><subject>Prostatic Neoplasms - pathology</subject><subject>TOCOFEROLES</subject><subject>TOCOPHEROL</subject><subject>TOCOPHEROLS</subject><subject>Tumor Cells, Cultured</subject><subject>Vitamin E - pharmacology</subject><issn>0006-291X</issn><issn>1090-2104</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kM1KxDAUhYMoOo5u3Ql5gY65Nm2TpRT_YEBBBXfhNk2dSKcZkqjMwofyRXwmU0d05eqQnHNybz5CjoDNgLHypGm8noGUYibzArbIBJhk2Skwvk0mLCWyUwmPe2Q_hGfGAHgpd8murATPRTUh7_O1diszGGoHehaC0xajdQN9s3FBPz-ye5f8hfGup9fDwjY2BoqR3i7WwbrePVmNPa3doM0Q_Xc10NuUtp3ZHKnrxosQMRpao9d2cEukten7cEB2OuyDOfzRKXm4OL-vr7L5zeV1fTbPdF5CzJqyqBCEaApegsBKIJdC8qrM0VSFQFaA4cAarJLorpWiFSg155C3bVGU-ZTMNu_qtEjwplMrb5fo1wqYGjGqEaMaMaoRYyocbwqrl2Zp2t_4D7c_v0On8MnboB7uUr1iAsbIlIiNb9KvXq3xKmhrEqTWeqOjap39b_QXibqNTA</recordid><startdate>19980929</startdate><enddate>19980929</enddate><creator>Pastori, Mariella</creator><creator>Pfander, Hanspeter</creator><creator>Boscoboinik, Daniel</creator><creator>Azzi, Angelo</creator><general>Elsevier Inc</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>19980929</creationdate><title>Lycopene in Association with α-Tocopherol Inhibits at Physiological Concentrations Proliferation of Prostate Carcinoma Cells</title><author>Pastori, Mariella ; Pfander, Hanspeter ; Boscoboinik, Daniel ; Azzi, Angelo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c361t-b657a188b54618a78a49894763ae758a051e410ba7e41cfd98d8a9c4413dd5563</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Antioxidants - pharmacology</topic><topic>CARCINOMA</topic><topic>Carcinoma - pathology</topic><topic>CARCINOME</topic><topic>Carotenoids - pharmacology</topic><topic>Cell Division - drug effects</topic><topic>CELLS</topic><topic>CELLULE</topic><topic>CELULAS</topic><topic>Drug Synergism</topic><topic>Humans</topic><topic>LICOPENO</topic><topic>LYCOPENE</topic><topic>Male</topic><topic>Prostatic Neoplasms - pathology</topic><topic>TOCOFEROLES</topic><topic>TOCOPHEROL</topic><topic>TOCOPHEROLS</topic><topic>Tumor Cells, Cultured</topic><topic>Vitamin E - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pastori, Mariella</creatorcontrib><creatorcontrib>Pfander, Hanspeter</creatorcontrib><creatorcontrib>Boscoboinik, Daniel</creatorcontrib><creatorcontrib>Azzi, Angelo</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Biochemical and biophysical research communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pastori, Mariella</au><au>Pfander, Hanspeter</au><au>Boscoboinik, Daniel</au><au>Azzi, Angelo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lycopene in Association with α-Tocopherol Inhibits at Physiological Concentrations Proliferation of Prostate Carcinoma Cells</atitle><jtitle>Biochemical and biophysical research communications</jtitle><addtitle>Biochem Biophys Res Commun</addtitle><date>1998-09-29</date><risdate>1998</risdate><volume>250</volume><issue>3</issue><spage>582</spage><epage>585</epage><pages>582-585</pages><issn>0006-291X</issn><eissn>1090-2104</eissn><abstract>The effect of lycopene alone or in association with other antioxidants was studied on the growth of two different human prostate carcinoma cell lines (the androgen insensitive DU-145 and PC-3). It was found that lycopene alone was not a potent inhibitor of prostate carcinoma cell proliferation. However, the simultaneous addition of lycopene together with α-tocopherol, at physiological concentrations (less than 1 μM and 50 μM, respectively), resulted in a strong inhibitory effect of prostate carcinoma cell proliferation, which reached values close to 90 %. The effect of lycopene with α-tocopherol was synergistic and was not shared by β-tocopherol, ascorbic acid and probucol.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>9784387</pmid><doi>10.1006/bbrc.1998.9351</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Biochemical and biophysical research communications, 1998-09, Vol.250 (3), p.582-585 |
| issn | 0006-291X 1090-2104 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Antioxidants - pharmacology CARCINOMA Carcinoma - pathology CARCINOME Carotenoids - pharmacology Cell Division - drug effects CELLS CELLULE CELULAS Drug Synergism Humans LICOPENO LYCOPENE Male Prostatic Neoplasms - pathology TOCOFEROLES TOCOPHEROL TOCOPHEROLS Tumor Cells, Cultured Vitamin E - pharmacology |
| title | Lycopene in Association with α-Tocopherol Inhibits at Physiological Concentrations Proliferation of Prostate Carcinoma Cells |
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