Functional Involvement of Serum Response Factor in the Transcriptional Regulation of Caldesmon Gene

A 22-bp fragment including the CArG element (CArG1) is essential for the transcription of the caldesmon gene. In this study, we investigated the effects of serum response factor (SRF) on the functional regulation of caldesmon promoter in smooth muscle cells. Gel supershift assay revealed that SRF wa...

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Veröffentlicht in:	Biochemical and biophysical research communications 1998-01, Vol.242 (2), p.429-435
Hauptverfasser:	Momiyama, Takuya, Hayashi, Ken'ichiro, Obata, Hideto, Chimori, Yoshihiro, Nishida, Toshirou, Ito, Toshinori, Kamiike, Wataru, Matsuda, Hikaru, Sobue, Kenji
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blotting, Northern Calmodulin-Binding Proteins - genetics Cell Differentiation - physiology Chick Embryo DNA-Binding Proteins - analysis DNA-Binding Proteins - metabolism Electrophoresis, Polyacrylamide Gel Gene Expression Regulation - genetics Genes, Reporter - genetics Mutagenesis, Site-Directed - genetics Nuclear Proteins - analysis Nuclear Proteins - isolation & purification Nuclear Proteins - metabolism Promoter Regions, Genetic - genetics RNA, Messenger - analysis Serum Response Factor Transcriptional Activation - genetics Transfection - genetics
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