Large Unphosphorylated Aggregates as the Active Form of hsp27 Which Controls Intracellular Reactive Oxygen Species and Glutathione Levels and Generates a Protection against TNFα in NIH-3T3-ras Cells

The mammalian small stress protein hsp27 is an oligomeric phosphoprotein which interferes with the cell death induced by several stimuli. In that sense, we and others have recently shown that human hsp27 expression induced cellular protection against tumor necrosis factor (TNFα), a protection which...

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Veröffentlicht in:	Biochemical and biophysical research communications 1997-12, Vol.241 (1), p.187-192
Hauptverfasser:	Mehlen, Patrick, Hickey, Eilen, Weber, Lee A., Arrigo, André-Patrick
Format:	Artikel
Sprache:	eng
Schlagworte:	cell death glutathione hsp27 phosphorylation mutant reactive oxygen species TNFα
Online-Zugang:	Volltext
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