Antibody-Based Therapy Targeting Tumor Vascular Endothelial Cells Suppresses Solid Tumor Growth in Rats

We have developed a new approach to antibody-based therapy of solid tumors by targeting tumor vascular endothelial cells (EC) which are essential for the growth of solid tumors. We investigated the effect of an antibody against tumor-derived endothelial cells (TEC) on the growth of solid tumors in r...

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Veröffentlicht in:	Biochemical and biophysical research communications 1997-07, Vol.236 (2), p.493-496
Hauptverfasser:	Ohizumi, Iwao, Tsunoda, Shin-ichi, Taniguchi, Kenji, Saito, Hiroyuki, Esaki, Keiko, Makimoto, Hiroo, Wakai, Yukiko, Tsutsumi, Yasuo, Nakagawa, Shinsaku, Utoguchi, Naoki, Kaiho, Shin-ichi, Ohsugi, Yoshiyuki, Mayumi, Tadanori
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - therapeutic use Antibody-Dependent Cell Cytotoxicity Endothelium, Vascular - cytology Endothelium, Vascular - immunology Female Immunotherapy Rats Sarcoma, Experimental - blood supply Sarcoma, Experimental - pathology Sarcoma, Experimental - therapy
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