7-Sulfooxymethyl-12-methylbenz[a]anthracene Is an Exceptionally Reactive Electrophilic Mutagen and Ultimate Carcinogen

The hypothesis was tested that an ultimate carcinogen of 7-hydroxymethyl-12-methylbenz[a]anthracene (HMBA), a major metabolite of 7,12-dimethylbenz[a]anthracene (DMBA), is a benzylic carbonium ion generated from an exceptionally reactive aralkylating metabolite, such as an electrophilic sulfate este...

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Veröffentlicht in:	Biochemical and biophysical research communications 1997-02, Vol.231 (1), p.144-148
Hauptverfasser:	Flesher, James W., Horn, Jamie, Lehner, Andreas F.
Format:	Artikel
Sprache:	eng
Schlagworte:	9,10-Dimethyl-1,2-benzanthracene - administration & dosage 9,10-Dimethyl-1,2-benzanthracene - analogs & derivatives 9,10-Dimethyl-1,2-benzanthracene - toxicity Animals Carcinogens - administration & dosage Carcinogens - toxicity Female Mutagens - administration & dosage Mutagens - toxicity Rats Rats, Sprague-Dawley Sarcoma, Experimental - chemically induced
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