Activity of the (R)-Enantiomers of 9-(2-Phosphonylmethoxypropyl)-Adenine and 9-(2-Phosphonylmethoxypropyl)-2,6-diaminopurine against Human Immunodeficiency Virus in Different Human Cell Systems

The (S)- and (R)-enantiomers of 9-(2-phosphonylmethoxypropyl) derivatives of adenine (PMPA) and 2,6-diaminopurine (PMPDAP) were evaluated for their inhibitory effect on HIV replication in several human cell systems, including natural peripheral blood lymphocytes (PBL) and freshly isolated monocyte/m...

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Veröffentlicht in:	Biochemical and biophysical research communications 1996-02, Vol.219 (2), p.337-341
Hauptverfasser:	Balzarini, J., Aquaro, S., Perno, C.-F., Witvrouw, M., Holý, A., De Clercq, E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenine - analogs & derivatives Adenine - pharmacology Antiviral Agents - pharmacology Cell Line Dose-Response Relationship, Drug HIV-1 - drug effects Humans Organophosphonates Organophosphorus Compounds - pharmacology Soman - analogs & derivatives Soman - pharmacology Stereoisomerism Structure-Activity Relationship Virus Replication - drug effects
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